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预测为肿瘤抑制因子的假定蛋白：蛋白质功能分析

Hypothetical protein predicted to be tumor suppressor: a protein functional analysis.

作者信息

Kader Md Abdul, Ahammed Akash, Khan Md Sharif, Ashik Sheikh Abdullah Al, Islam Md Shariful, Hossain Mohammad Uzzal

机构信息

Department of Biotechnology and Genetic Engineering, Mawlana Bhashani Science and Technology University, Tangail 1902, Bangladesh.

University of Kentucky, Lexington, KY 40506, USA.

出版信息

Genomics Inform. 2022 Mar;20(1):e6. doi: 10.5808/gi.21073. Epub 2022 Mar 31.

DOI:10.5808/gi.21073
PMID:35399005
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9002001/
Abstract

Litorilituus sediminis is a Gram-negative, aerobic, novel bacterium under the family of Colwelliaceae, has a stunning hypothetical protein containing domain called von Hippel-Lindau that has significant tumor suppressor activity. Therefore, this study was designed to elucidate the structure and function of the biologically important hypothetical protein EMK97_00595 (QBG34344.1) using several bioinformatics tools. The functional annotation exposed that the hypothetical protein is an extracellular secretory soluble signal peptide and contains the von Hippel-Lindau (VHL; VHL beta) domain that has a significant role in tumor suppression. This domain is conserved throughout evolution, as its homologs are available in various types of the organism like mammals, insects, and nematode. The gene product of VHL has a critical regulatory activity in the ubiquitous oxygen-sensing pathway. This domain has a significant role in inhibiting cell proliferation, angiogenesis progression, kidney cancer, breast cancer, and colon cancer. At last, the current study depicts that the annotated hypothetical protein is linked with tumor suppressor activity which might be of great interest to future research in the higher organism.

摘要

沉积物滨藜弧菌是一种革兰氏阴性、需氧的新型细菌，属于考氏菌科，有一种令人惊叹的含有称为冯·希佩尔-林道结构域的假定蛋白，该结构域具有显著的肿瘤抑制活性。因此，本研究旨在使用多种生物信息学工具阐明具有重要生物学意义的假定蛋白EMK97_00595（QBG34344.1）的结构和功能。功能注释表明，该假定蛋白是一种细胞外分泌可溶性信号肽，含有在肿瘤抑制中起重要作用的冯·希佩尔-林道（VHL；VHLβ）结构域。该结构域在整个进化过程中都是保守的，因为其同源物存在于各种生物体中，如哺乳动物、昆虫和线虫。VHL的基因产物在普遍存在的氧感应途径中具有关键的调节活性。该结构域在抑制细胞增殖、血管生成进程、肾癌、乳腺癌和结肠癌方面具有重要作用。最后，本研究表明，注释的假定蛋白与肿瘤抑制活性有关，这可能对高等生物的未来研究具有重要意义。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2396/9002001/111733441909/gi-21073f10.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2396/9002001/f895d66a993c/gi-21073f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2396/9002001/8683db7f734a/gi-21073f2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2396/9002001/155c0956a8d4/gi-21073f3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2396/9002001/db6204dbcbcf/gi-21073f4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2396/9002001/0cd1db7af9c3/gi-21073f5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2396/9002001/773c457163a5/gi-21073f6.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2396/9002001/796ba0ba0231/gi-21073f7.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2396/9002001/292446d89968/gi-21073f8.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2396/9002001/632cfe535a79/gi-21073f9.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2396/9002001/111733441909/gi-21073f10.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2396/9002001/f895d66a993c/gi-21073f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2396/9002001/8683db7f734a/gi-21073f2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2396/9002001/155c0956a8d4/gi-21073f3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2396/9002001/db6204dbcbcf/gi-21073f4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2396/9002001/0cd1db7af9c3/gi-21073f5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2396/9002001/773c457163a5/gi-21073f6.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2396/9002001/796ba0ba0231/gi-21073f7.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2396/9002001/292446d89968/gi-21073f8.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2396/9002001/632cfe535a79/gi-21073f9.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2396/9002001/111733441909/gi-21073f10.jpg

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