氨基糖苷类抗生素的酶促修饰：具有广泛特异性的3-N-乙酰基转移酶，其决定对新型氨基糖苷类抗生素阿泊拉霉素的耐药性。
Enzymatic modification of aminoglycoside antibiotics: 3-N-acetyltransferase with broad specificity that determines resistance to the novel aminoglycoside apramycin.
作者信息
Davies J, O'Connor S
出版信息
Antimicrob Agents Chemother. 1978 Jul;14(1):69-72. doi: 10.1128/AAC.14.1.69.
Abstract
Examination of a number of R-plasmid-containing bacterial isolates of animal origin has revealed the presence of a new aminoglycoside acetyltransferase (3-N) with a broad substrate range that includes all the disubstituted 2-deoxystreptamine antibiotics and also the novel monosubstituted antibiotic apramycin. Antibiotic derivatives acylated with hydroxyaminobutyric acid at the 1-amino position were not modified by the enzyme.
摘要
对多个源自动物的含有R质粒的细菌分离株进行检测后发现，存在一种新的氨基糖苷乙酰转移酶（3-N），其底物范围广泛，包括所有双取代的2-脱氧链霉胺抗生素以及新型单取代抗生素阿泊拉霉素。在1-氨基位置被羟基氨基丁酸酰化的抗生素衍生物不会被该酶修饰。
相似文献
1
Enzymatic modification of aminoglycoside antibiotics: 3-N-acetyltransferase with broad specificity that determines resistance to the novel aminoglycoside apramycin.
Antimicrob Agents Chemother. 1978 Jul;14(1):69-72. doi: 10.1128/AAC.14.1.69.
2
ApmA Is a Unique Aminoglycoside Antibiotic Acetyltransferase That Inactivates Apramycin.
mBio. 2021 Feb 9;12(1):e02705-20. doi: 10.1128/mBio.02705-20.
3
Resistance to apramycin in Escherichia coli isolated from animals: detection of a novel aminoglycoside-modifying enzyme.
J Gen Microbiol. 1984 Mar;130(3):473-82. doi: 10.1099/00221287-130-3-473.
4
AAC(1): a new aminoglycoside-acetylating enzyme modifying the Cl aminogroup of apramycin.
J Antimicrob Chemother. 1987 Dec;20(6):803-13. doi: 10.1093/jac/20.6.803.
5
Apramycin and gentamicin resistance in Escherichia coli and salmonellas isolated from farm animals.
J Hyg (Lond). 1986 Dec;97(3):445-56. doi: 10.1017/s0022172400063622.
6
Human isolates of apramycin-resistant Escherichia coli which contain the genes for the AAC(3)IV enzyme.
Epidemiol Infect. 1993 Apr;110(2):253-9. doi: 10.1017/s0950268800068175.
7
Apralogs: Apramycin 5--Glycosides and Ethers with Improved Antibacterial Activity and Ribosomal Selectivity and Reduced Susceptibility to the Aminoacyltranserferase (3)-IV Resistance Determinant.
J Am Chem Soc. 2020 Jan 8;142(1):530-544. doi: 10.1021/jacs.9b11601. Epub 2019 Dec 17.
8
Gentamicin resistance in clinical isolates of Escherichia coli encoded by genes of veterinary origin.
J Med Microbiol. 1994 Mar;40(3):221-6. doi: 10.1099/00222615-40-3-221.
9
Epidemiologic, Phenotypic, and Structural Characterization of Aminoglycoside-Resistance Gene .
Int J Mol Sci. 2020 Aug 25;21(17):6133. doi: 10.3390/ijms21176133.
10
Resistance to apramycin in two enterobacterial clinical isolates: detection of a 3-N-acetyltransferase IV.
J Chemother. 1990 Aug;2(4):241-3. doi: 10.1080/1120009x.1990.11739023.
引用本文的文献
1
Comparison of antimicrobial resistant Escherichia coli isolated from Irish commercial pig farms with and without zinc oxide and antimicrobial usage.
Gut Pathog. 2023 Feb 24;15(1):8. doi: 10.1186/s13099-023-00534-3.
2
Detection of the and aac (3)-1V resistance genes in .
Arch Razi Inst. 2022 Jun 30;77(3):959-966. doi: 10.22092/ari.2022.357271.2010. eCollection 2022 Jun.
3
Repurposing the Veterinary Antibiotic Apramycin for Antibacterial and Antibiofilm Activity Against From Cystic Fibrosis Patients.
Front Microbiol. 2022 Feb 3;12:801152. doi: 10.3389/fmicb.2021.801152. eCollection 2021.
4
ApmA Is a Unique Aminoglycoside Antibiotic Acetyltransferase That Inactivates Apramycin.
mBio. 2021 Feb 9;12(1):e02705-20. doi: 10.1128/mBio.02705-20.
5
Epidemiologic, Phenotypic, and Structural Characterization of Aminoglycoside-Resistance Gene .
Int J Mol Sci. 2020 Aug 25;21(17):6133. doi: 10.3390/ijms21176133.
6
Wild-type cutoff for Apramycin against Escherichia coli.
BMC Vet Res. 2020 Aug 26;16(1):309. doi: 10.1186/s12917-020-02522-0.
7
Apralogs: Apramycin 5--Glycosides and Ethers with Improved Antibacterial Activity and Ribosomal Selectivity and Reduced Susceptibility to the Aminoacyltranserferase (3)-IV Resistance Determinant.
J Am Chem Soc. 2020 Jan 8;142(1):530-544. doi: 10.1021/jacs.9b11601. Epub 2019 Dec 17.
8
Evaluation of apramycin against spectinomycin-resistant and -susceptible strains of Neisseria gonorrhoeae.
J Antimicrob Chemother. 2019 May 1;74(5):1311-1316. doi: 10.1093/jac/dkz012.
9
In vitro activity of apramycin against multidrug-, carbapenem- and aminoglycoside-resistant Enterobacteriaceae and Acinetobacter baumannii.
J Antimicrob Chemother. 2019 Apr 1;74(4):944-952. doi: 10.1093/jac/dky546.
10
Characterization of Resistance Patterns and Detection of Apramycin Resistance Genes in Isolated from Chicken Feces and Houseflies after Apramycin Administration.
Front Microbiol. 2018 Feb 27;9:328. doi: 10.3389/fmicb.2018.00328. eCollection 2018.
本文引用的文献
1
Resistance of Pseudomonas aeruginosa to gentamicin and related aminoglycoside antibiotics.
Antimicrob Agents Chemother. 1974 Sep;6(3):253-62. doi: 10.1128/AAC.6.3.253.
2
13C-NMR studies on ribostamycin and its related compounds.
J Antibiot (Tokyo). 1973 Dec;26(12):717-24. doi: 10.7164/antibiotics.26.717.
3
Gentamicin resistance in strains of Pseudomonas aeruginosa mediated by enzymatic N-acetylation of the deoxystreptamine moiety.
Biochemistry. 1972 Feb 29;11(5):761-5. doi: 10.1021/bi00755a013.
4
Mechanisms of antibiotic resistance in bacteria.
Annu Rev Biochem. 1973;42:471-506. doi: 10.1146/annurev.bi.42.070173.002351.
5
Carbon-13 nuclear magnetic resonance spectroscopy of naturally occurring substances. XXXIX. Apramycin--an application of amine protonation parameters.
J Org Chem. 1976 Feb 20;41(4):701-2. doi: 10.1021/jo00866a025.
6
Apramycin, a unique aminocyclitol antibiotic.
J Org Chem. 1976 Jun 11;41(12):2087-92. doi: 10.1021/jo00874a003.
7
Simple agarose gel electrophoretic method for the identification and characterization of plasmid deoxyribonucleic acid.
J Bacteriol. 1976 Sep;127(3):1529-37. doi: 10.1128/jb.127.3.1529-1537.1976.
8
Enzymatic modification of aminoglycoside antibiotics: a new 3-N-acetylating enzyme from a Pseudomonas aeruginosa isolate.
Antimicrob Agents Chemother. 1976 Jun;9(6):951-5. doi: 10.1128/AAC.9.6.951.
9
Enzymatic modification of aminoglycoside antibiotics: a new 6'-N-acetylating enzyme from a Pseudomonas aeruginosa isolate.
Antimicrob Agents Chemother. 1976 Jun;9(6):945-50. doi: 10.1128/AAC.9.6.945.
10
Enzymatic acetylation of fortimicin A and seldomycin factor 5 by aminoglycoside 3-acetyltransferase I: [AAC(3)-I] of E. coli KY8348.
J Antibiot (Tokyo). 1977 Nov;30(11):1025-7. doi: 10.7164/antibiotics.30.1025.
Zotero 插件