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Brugada综合征心脏性猝死的危险分层：文献综述更新

Risk stratification of sudden cardiac death in Brugada syndrome: an updated review of literature.

作者信息

Darar Charmake, Mohammed El-Azrak, Mohammed Boutaybi, Noha El Ouafi, Zakaria Bazid

机构信息

Departement of Cardiology, Mohammed VI University Hospital, Faculty of Medicine and Pharmacy, Oujda/Mohammed I University, Oujda, Morocco.

Epidemiological Laboratory of Clinical Research and Public Health, Mohammed VI University Hospital, Oujda, Morocco.

出版信息

Egypt Heart J. 2022 Apr 11;74(1):25. doi: 10.1186/s43044-022-00267-9.

DOI:10.1186/s43044-022-00267-9
PMID:35404008
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9001772/
Abstract

Brugada syndrome is a rare but serious inherited heart disease that causes sudden cardiac death by polymorphic ventricular tachycardia or ventricular fibrillation. It is an autosomal dominant genetic disease that usually occurs in patients in their forties with a structurally normal heart. Electrically, it manifests by ST elevation segment ≥ 2 mm of at least one right precordial lead (V1 and/or V2). Stratification of sudden cardiac death in Brugada syndrome is not always easy and constitutes a real challenge for the practitioner. In this review, we will present the current state of knowledge for arrhythmic risk stratification and the prevention of sudden cardiac death that can result from this syndrome.

摘要

Brugada综合征是一种罕见但严重的遗传性心脏病，可通过多形性室性心动过速或心室颤动导致心源性猝死。它是一种常染色体显性遗传病，通常发生在40多岁、心脏结构正常的患者中。在心电图上，它表现为至少一个右胸前导联（V1和/或V2）的ST段抬高≥2毫米。对Brugada综合征的心源性猝死进行分层并不总是容易的，对医生来说是一项真正的挑战。在这篇综述中，我们将介绍心律失常风险分层以及预防该综合征可能导致的心源性猝死的当前知识状态。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9177/9001772/6e72c6623fe9/43044_2022_267_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9177/9001772/6e72c6623fe9/43044_2022_267_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9177/9001772/6e72c6623fe9/43044_2022_267_Fig1_HTML.jpg

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Role of syncope in predicting adverse outcomes in patients with suspected Brugada syndrome undergoing standardized flecainide testing.晕厥在疑似 Brugada 综合征患者行标准化氟卡尼试验中对不良预后的预测作用。
Europace. 2018 Jun 1;20(FI1):f64-f71. doi: 10.1093/europace/eux315.
2
2017 AHA/ACC/HRS Guideline for Management of Patients With Ventricular Arrhythmias and the Prevention of Sudden Cardiac Death: Executive Summary: A Report of the American College of Cardiology/American Heart Association Task Force on Clinical Practice Guidelines and the Heart Rhythm Society.2017年美国心脏协会/美国心脏病学会/心律学会室性心律失常患者管理和心脏性猝死预防指南：执行摘要：美国心脏病学会/美国心脏协会临床实践指南工作组及心律学会的报告
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The Action Potential Clamp Technique as a Tool for Risk Stratification of Sinus Bradycardia Due to Loss-of-Function Mutations in HCN4: An In Silico Exploration Based on In Vitro and In Vivo Data.动作电位钳技术作为一种对由HCN4功能丧失突变引起的窦性心动过缓进行风险分层的工具：基于体外和体内数据的计算机模拟探索。
Biomedicines. 2023 Sep 2;11(9):2447. doi: 10.3390/biomedicines11092447.
Prognosis, risk stratification, and management of asymptomatic individuals with Brugada syndrome: A systematic review.Brugada综合征无症状个体的预后、风险分层及管理：一项系统评价
Pacing Clin Electrophysiol. 2017 Dec;40(12):1332-1345. doi: 10.1111/pace.13214. Epub 2017 Nov 15.
4
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5
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