Qiushi Academy for Advanced Studies, Zhejiang University, Hangzhou 310027, China.
Center for Biomaterials and Biopathways, Department of Chemistry, Zhejiang University, Hangzhou 310027, China.
J Inorg Biochem. 2022 Jul;232:111815. doi: 10.1016/j.jinorgbio.2022.111815. Epub 2022 Apr 6.
Biomineralization refers to a native biosynthesis process whereby the organisms fabricate hierarchical organic-inorganic composites for life maintenance, growth, and biological evolution. Motivated by these outstanding advantages, scientists endeavor to reproduce the manufacturing strategies and structural features of biomineralization by means of synergetic combination of inorganic materials and bioactive organisms. Thus, following the identified mechanisms of biomineralization, the biomimetic mineralization is becoming an emerging research field for designing and engineering organisms. In the present review, we summarize the recent achievements in understanding and applications of biomineralization-based organisms engineering. Aiming at design of application-oriented material-organism hybrids, we pay attention to the strategies that can endow organisms, such as viruses, bacteria, and cells, with addressable structures and excellent physiological properties, which can thereby facilitate the unnatural functions including environmental resistance, biological enhancement, tumor therapy, and cell-based delivery. By summarizing the recent research focus, we hope to provide an alternative understanding for the design and application of organism-material hybrid using biomineralization-inspired engineering.
生物矿化是指生物体通过固有生物合成过程来制造分级的有机-无机复合材料，以维持生命、促进生长和进行生物进化。受这些突出优点的启发，科学家们努力通过无机材料和生物活性生物体的协同组合来复制生物矿化的制造策略和结构特征。因此，根据生物矿化的明确机制，基于仿生矿化的生物体工程正在成为一个新兴的研究领域，用于设计和工程生物体。在本综述中，我们总结了基于生物矿化的生物体工程理解和应用的最新进展。为了设计面向应用的材料-生物体杂化体，我们关注可以赋予病毒、细菌和细胞等生物体可寻址结构和优异生理特性的策略，从而促进包括环境抗性、生物增强、肿瘤治疗和基于细胞的递药在内的非自然功能。通过总结最近的研究重点，我们希望为使用受生物矿化启发的工程设计和应用生物体-材料杂化体提供一种替代理解。
