Furukawa Tomoko, Yokono Chisako, Nomura Yoshihiro
Scleroprotein and Leather Research Institute, Faculty of Agriculture, Tokyo University of Agriculture and Technology, 3-5-8 Saiwai cho, Fuchu shi, Tokyo, 183-8509 Japan.
Cytotechnology. 2024 Jun;76(3):271-277. doi: 10.1007/s10616-024-00615-4. Epub 2024 Feb 27.
Immature mandarin orange is thinned in order to maturation of orange. To use immature mandarin orange as a cosmetic functional material, we investigated the seasonal fluctuation changes in hesperidin and narirutin levels of immature mandarin oranges, and the effects on human skin cells. The contents of hesperidin from Aoshima, Otsu, and Shonan gold, is higher at about a month after flowering. Shonan gold has higher content of narirutin to compere that of Aoshima and Otsu. We found the addition of immature mandarin orange extracts to the human skin fibroblasts and keratinocytes, gene expression level of hyaluronic acid synthase and the hyaluronic acid contents in the medium are higher than that of the control. It was suggested that hesperidin in immature mandarin orange enhances the ability of skin cells to produce hyaluronic acid. Our findings indicate that the immature mandarin orange is a characteristic material on cosmetics and functional foods.
为了使橙子成熟，会疏果未成熟的柑橘。为了将未成熟的柑橘用作化妆品功能材料，我们研究了未成熟柑橘中橙皮苷和柚皮芸香苷含量的季节性波动变化，以及对人体皮肤细胞的影响。青岛、大津和湘南黄金的橙皮苷含量在开花后约一个月时较高。与青岛和大津相比，湘南黄金的柚皮芸香苷含量更高。我们发现，在人皮肤成纤维细胞和角质形成细胞中添加未成熟柑橘提取物后，透明质酸合酶的基因表达水平和培养基中的透明质酸含量均高于对照组。这表明未成熟柑橘中的橙皮苷增强了皮肤细胞产生透明质酸的能力。我们的研究结果表明，未成熟柑橘是化妆品和功能性食品的特色原料。
