Rowe N H, Aseltine L F, Turner J L
Oral Surg Oral Med Oral Pathol. 1985 May;59(5):446-8. doi: 10.1016/0030-4220(85)90078-7.
The analgesic effectiveness of meclofenamate sodium (Meclomen) at two dose levels, 200 mg and 100 mg, was compared with the effectiveness of a placebo and aspirin, 600 mg, in a double-blind study of 174 adult outpatients who had undergone removal of impacted third molars. When compared with the placebo, meclofenamate sodium at either dose level produced a significantly greater reduction in pain intensity, greater pain relief, fewer withdrawals for inefficacy, greater percentage of patients who considered their medication effective, and greater percentage of patients considered by the investigator to have received drug-attributable benefits. In comparison with aspirin, 600 mg, meclofenamate sodium at either 200 mg or 100 mg produced significantly greater reduction in pain intensity and greater pain relief. The other measures of efficacy showed no significant differences between the two drugs. Side effects were minimal in all treatment groups. Meclofenamate sodium appears to be a safe and effective analgesic for the control of pain.
在一项针对174名拔除阻生第三磨牙的成年门诊患者的双盲研究中，比较了两种剂量水平（200毫克和100毫克）的甲氯芬那酸钠（甲氯灭酸）与安慰剂及600毫克阿司匹林的镇痛效果。与安慰剂相比，任一剂量水平的甲氯芬那酸钠在疼痛强度降低方面均显著更大，疼痛缓解程度更高，因无效而退出的人数更少，认为其药物有效的患者百分比更高，且研究者认为获得药物相关益处的患者百分比更高。与600毫克阿司匹林相比，200毫克或100毫克的甲氯芬那酸钠在疼痛强度降低和疼痛缓解方面均显著更大。其他疗效指标显示两种药物之间无显著差异。所有治疗组的副作用均最小。甲氯芬那酸钠似乎是一种控制疼痛的安全有效的镇痛药。
