Department of Cell and Molecular Biology, Faculty of Life Sciences and Technology, Shahid Beheshti University, Tehran, Iran.
Skull Base Research Center, Loghman Hakim Hospital, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
BMC Psychiatry. 2022 Apr 12;22(1):256. doi: 10.1186/s12888-022-03899-y.
Long non-coding RNAs (lncRNAs) have been recently emerged as critical modulators of oxidative stress pathway. Likewise, rising evidence currently highlights dysfunction of oxidative stress pathways in bipolar disorder (BD) patients.In the current study, we evaluated the expression levels of H19, SCAL1 (LUCAT1), RMST, MEG3 and MT1DP lncRNAs in the PBMC from 50 patients with BD and 50 control subjects (male/female ratio in each group: 70%/30%). Expression levels of SCAL1, RMST and MEG3 but not H19 and MT1DP were considerably decreased in BD patients compared with healthy individuals. Such significant decrease in the expression of MEG3, RMST and SCAL1 was only reported in male BD patients compared with male controls. Substantial pairwise correlations were observed between expression levels of these lncRNAs in BD subjects. The area under curve values for RMST, MEG3 and SCAL1 were 0.70, 0.63 and 0.61 respectively. On the basis of this finding, RMST had the best efficiency in the discrimination of disease status between BD patients and controls. Taken together, the current results suggest a role for MEG3, RMST and SCAL1 lncRNAs in the pathogenesis of BD. In addition, peripheral expression levels of these lncRNAs might serve as potential peripheral markers for BD.
长链非编码 RNA（lncRNA）最近被认为是氧化应激途径的关键调节因子。同样，目前越来越多的证据强调氧化应激途径在双相情感障碍（BD）患者中的功能障碍。在本研究中，我们评估了 50 名 BD 患者和 50 名对照个体（每组男女比例：70%/30%）的 PBMC 中 H19、SCAL1（LUCAT1）、RMST、MEG3 和 MT1DP lncRNA 的表达水平。与健康个体相比，BD 患者的 SCAL1、RMST 和 MEG3 的表达水平明显降低，但 H19 和 MT1DP 则不然。与男性对照相比，仅在男性 BD 患者中观察到 MEG3、RMST 和 SCAL1 的表达显著降低。在 BD 患者中，这些 lncRNA 的表达水平之间存在显著的两两相关性。RMST、MEG3 和 SCAL1 的曲线下面积值分别为 0.70、0.63 和 0.61。基于这一发现，RMST 在区分 BD 患者和对照组的疾病状态方面具有最佳效率。总之，目前的结果表明 MEG3、RMST 和 SCAL1 lncRNA 在 BD 的发病机制中起作用。此外，这些 lncRNA 的外周表达水平可能作为 BD 的潜在外周标志物。
