Department of Occupational and Environmental Medicine, Kangbuk Samsung Hospital, School of Medicine, Sungkyunkwan University, Seoul 03181, Korea.
Int J Environ Res Public Health. 2022 Sep 19;19(18):11831. doi: 10.3390/ijerph191811831.
Long working hours have negative effects on the health of workers. Several studies have reported the association between long working hours and both diabetes and prediabetes. Therefore, we aimed to examine the temporal relationship between long working hours and glucose intolerance. Our cohort study collected data from 25,803 healthy male participants at baseline. To evaluate the risk of incident glucose intolerance, we estimated the hazard ratios (HRs) and 95% confidence intervals (CIs) using the Cox proportional hazards regression analyses. During 77,605.0 person-years of follow-up, 6741 participants developed glucose intolerance. Multivariable-adjusted HRs (95% CI) for weekly working 41-52 and >52 h compared with working 35-40 h, were 1.28 (1.17-1.40) and 2.80 (2.54-3.09), respectively. In the dose-response analyses, long working hours had a nearly linear relationship with the development of glucose intolerance across most working hours per week. The association between long working hours and incident glucose intolerance was stronger in the younger-age subgroups than in the older-age subgroups ( for interaction <0.001). Our large-scale cohort study demonstrated that long working hours were associated with incident glucose intolerance, with a dose-response relationship.
长时间工作对工人的健康有负面影响。几项研究报告了长时间工作与糖尿病和糖尿病前期之间的关联。因此，我们旨在研究长时间工作与葡萄糖耐量之间的时间关系。我们的队列研究在基线时收集了 25803 名健康男性参与者的数据。为了评估新发葡萄糖耐量的风险，我们使用 Cox 比例风险回归分析估计了风险比 (HR) 和 95%置信区间 (CI)。在 77605.0 人年的随访期间，6741 名参与者出现葡萄糖耐量异常。与每周工作 35-40 小时相比，每周工作 41-52 小时和>52 小时的多变量调整 HR（95%CI）分别为 1.28（1.17-1.40）和 2.80（2.54-3.09）。在剂量反应分析中，长时间工作与葡萄糖耐量异常的发展之间存在几乎线性的关系，每周工作时间大多如此。与年龄较大的亚组相比，年轻亚组中长时间工作与新发葡萄糖耐量异常之间的关联更强（交互作用<0.001）。我们的大规模队列研究表明，长时间工作与新发葡萄糖耐量异常有关，存在剂量反应关系。
