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免疫功能正常的男性患者发生内源性眼内炎:治疗结果和扫频源光相干断层扫描的发现。

endogenous endophthalmitis in an immunocompetent man: treatment outcomes and swept-source optical coherence tomography findings.

机构信息

Uvea, Ophthalmology, Neoretina Eye Institute, Hyderabad, India.

Retina, Ophthalmology, Neoretina Eye Institute, Hyderabad, India

出版信息

BMJ Case Rep. 2022 Apr 19;15(4):e245260. doi: 10.1136/bcr-2021-245260.

Abstract

A non-diabetic man in his 40s presented with a 4-day history of sudden, painless, rapidly progressive severe vision loss in his right eye. Anterior segment was unremarkable. A dense, solitary vitreous abscess with feathery margins obscured the macula. Retinal haemorrhages, exudates and retinal vasculitis were noted. There was no history of ocular surgery, trauma, intravenous drug abuse or immunocompromise. He received intravenous fluids during a spinal procedure 5 days prior. Prompt diagnostic and therapeutic pars-plana vitrectomy was done and was cultured. Postoperatively, he was treated with oral Voriconazole and four intravitreal Voriconazole injections, till the chorioretinitis lesions had completely healed and was objectively confirmed on follow-up swept-source optical coherence tomography (OCT). He achieved a best-corrected visual acuity of 6/36. A high index of suspicion, early vitrectomy and OCT-based treatment were key to favourable outcomes in this case. Intravenous fluid bottles must be checked for contamination prior to administration.

摘要

一位 40 多岁的非糖尿病男性,右眼突发无痛性、进行性视力丧失 4 天。眼前段无明显异常。浓密的孤立玻璃体脓肿,边界呈羽毛状,黄斑区模糊不清。可见视网膜出血、渗出和视网膜血管炎。患者无眼部手术、外伤、静脉内药物滥用或免疫功能低下的病史。他在 5 天前接受脊椎手术期间接受了静脉输液。立即进行了标准的经睫状体平坦部玻璃体切除术,并进行了培养。术后,他接受了口服伏立康唑和 4 次玻璃体内伏立康唑注射治疗,直到脉络膜视网膜炎病变完全愈合,并在后续的扫频源光学相干断层扫描(OCT)上得到客观证实。他的最佳矫正视力达到了 6/36。在这种情况下,高度怀疑、早期玻璃体切除术和基于 OCT 的治疗是取得良好结果的关键。在给药前必须检查静脉输液瓶是否受到污染。

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