The Chemically Highly Diversified Metabolites from the Red Sea Marine Sponge sp.

A polyoxygenated and halogenated labdane, spongianol (); a polyoxygenated steroid, 3β,5α,9α-trihydroxy-24-ethylcholest-7-en-6-one (); a rare seven-membered lactone B ring, (22,24)-ergosta-7,22-dien-3β,5α-diol-6,5-olide (); and an α,β-unsaturated fatty acid, ()-3-methyl-9-oxodec-2-enoic acid () as well as five known compounds, 10-hydroxykahukuene B (), pacifenol (), dysidamide (), 7,7,7-trichloro-3-hydroxy-2,2,6-trimethyl-4-(4,4,4-trichloro-3-methyl-1-oxobu-tylamino)-heptanoic acid methyl ester (), and the primary metabolite 2'-deoxynucleoside thymidine (), have been isolated from the Red Sea sponge sp. The stereoisomer of was discovered in , and metabolites and , isolated previously from red algae, were characterized unprecedentedly in the sponge. Compounds and have not been found before in the genus . Compounds - were also assayed for cytotoxicity as well as antibacterial and anti-inflammatory activities.