Doctoral Degree Program in Marine Biotechnology, National Sun Yat-sen University, Kaohsiung 80424, Taiwan.
Department of Pharmacognosy, College of Pharmacy, King Saud University, Riyadh 11451, Saudi Arabia.
Mar Drugs. 2022 Aug 1;20(8):498. doi: 10.3390/md20080498.
Three new 5,5,6,6,5-pentacyclic spongian diterpenes, spongenolactones A-C (-), were isolated from a Red Sea sponge sp. The structures of the new metabolites were elucidated by extensive spectroscopic analysis and the absolute configurations of were determined on the basis of comparison of the experimental circular dichroism (CD) and calculated electronic circular dichroism (ECD) spectra. Compounds - are the first 5,5,6,6,5-pentacyclic spongian diterpenes bearing an -hydroxy group at C-1. These metabolites were assayed for their cytotoxic, antibacterial, and anti-inflammatory activities. All three compounds were found to exert inhibitory activity against superoxide anion generation in fMLF/CB-stimulated human neutrophils. Furthermore, showed a higher activity against the growth of in comparison to .
三种新的 5,5,6,6,5-五环海绵二萜，spongenolactones A-C(-)，从一种红海海绵中分离得到。通过广泛的光谱分析阐明了新代谢物的结构，并根据实验圆二色性（CD）和计算电子圆二色性（ECD）光谱的比较确定了的绝对构型。-是第一个在 C-1 位带有-羟基的 5,5,6,6,5-五环海绵二萜。对这些代谢物进行了细胞毒性、抗菌和抗炎活性测定。所有三种化合物都显示出对 fMLF/CB 刺激的人中性粒细胞中超氧阴离子生成的抑制活性。此外，与相比，显示出对生长的更高抑制活性。
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