Kim Yu-Rin, Nam Seoul-Hee
Department of Dental Hygiene, Silla University, Busan 46958, Korea.
Department of Dental Hygiene, College of Health Sciences, Kangwon National University, Samcheok 25949, Korea.
Antibiotics (Basel). 2022 Apr 5;11(4):488. doi: 10.3390/antibiotics11040488.
This study was performed to verify the clinical effect of a mouthwash containing extract on the acid production of oral bacteria and bacteria involved in dental caries. A randomized, double-blind, and placebo-controlled trial was conducted on 66 patients of the following groups: a extract gargle group ( = 34) and a saline solution gargle group ( = 32). According to the application time of a mouthwash (before gargle application, immediately after gargle application, and five days after gargle application), we examined the emergence of dental caries-causing bacteria by PCR analysis and changes in the amount of acid production in dental plaque through a Cariview test. As a result of verifying the effect of inhibiting and preventing dental caries in the oral environment, the dental caries-causing bacteria decreased in the extract gargle group compared to the saline gargle group. In particular, showed a marked decrease from immediately after application of gargle to 5 days after application. In addition, the mouthwash containing extract did not cause acid production and had low dental caries activity. A mouthwash containing extract, a natural substance, can be used as an anti-dental caries agent and be commercialized as an effective dental caries prevention agent that is safe for teeth and has an excellent antibacterial effect.
本研究旨在验证含提取物的漱口水对口腔细菌产酸及致龋菌的临床效果。对66例患者进行了一项随机、双盲、安慰剂对照试验，分为以下两组：提取物漱口组（n = 34）和盐溶液漱口组（n = 32）。根据漱口水的使用时间（漱口前、漱口后即刻、漱口后5天），通过PCR分析检测致龋菌的出现情况，并通过Cariview测试检测牙菌斑中产酸量的变化。在验证口腔环境中抑制和预防龋齿的效果时，与盐水漱口组相比，提取物漱口组的致龋菌减少。特别是，从漱口后即刻到漱口后5天，[具体物质]显著减少。此外，含提取物的漱口水不产酸且龋齿活性低。含提取物的漱口水作为一种天然物质，可作为防龋剂使用，并可作为一种对牙齿安全且具有优异抗菌效果的有效防龋剂进行商业化。
