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一种含 提取物的漱口液预防龋齿的随机、双盲、安慰剂对照临床试验。

A Randomized, Double-Blind, Placebo-Controlled Clinical Trial of a Mouthwash Containing Extract for Preventing Dental Caries.

机构信息

Department of Dental Hygiene, Silla University, Busan 46958, Korea.

Department of Dental Hygiene, College of Health Sciences, Kangwon National University, Samcheok 25949, Korea.

出版信息

Int J Environ Res Public Health. 2021 Dec 26;19(1):242. doi: 10.3390/ijerph19010242.

DOI:10.3390/ijerph19010242
PMID:35010502
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8751079/
Abstract

This study sought to confirm the effect of using a mouthwash containing extract for oral health management by investigating changes in the pH of dental plaque and bacteria that cause dental caries. A randomized, double-blind, placebo-controlled study was conducted on 60 subjects categorized in either the extract gargle group ( = 30) or the saline gargle group ( = 30). Scaling was conducted in order to ensure the homogeneity of the oral environment, while gargling was performed once daily before the subjects went to bed for 5 days based on the group. Caries activity was assessed using the Cariview test, while detection of the bacteria that cause dental caries was confirmed using microbiological analysis. All clinical measurements and evaluations were conducted by two trained dental hygienists under the supervision of a dentist. Based on the analysis of dental caries activity and dental caries-causing bacteria, the extract gargle group showed a clear decrease in bacteria compared to the saline gargle group. extract demonstrated no risk of tooth demineralization. It also showed excellent antibacterial activity through inhibition and effective reduction of bacteria that cause dental caries. Therefore, the mouthwash containing extract is an effective oral care product suitable for use as an effective dental caries prevention agent.

摘要

本研究旨在通过调查含漱液对口腔健康管理中牙菌斑 pH 值和致龋菌的影响,确认使用含 提取物的漱口水的效果。将 60 名受试者随机分为 提取物含漱组(n = 30)或生理盐水含漱组(n = 30),进行了一项随机、双盲、安慰剂对照研究。为了确保口腔环境的均一性,进行了洁治,然后根据组别,每天睡前含漱一次,连续 5 天。使用 Cariview 试验评估龋齿活性,并用微生物分析确认致龋菌的存在。所有临床测量和评估均由两名经过培训的口腔保健师在牙医的监督下进行。基于龋齿活性和致龋菌的分析,与生理盐水含漱组相比,提取物含漱组的细菌明显减少。提取物不会导致牙齿脱矿。它还通过抑制和有效减少致龋菌,表现出优异的抗菌活性。因此,含 提取物的漱口水是一种有效的口腔护理产品,可作为有效的龋齿预防剂。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ea2d/8751079/19cde518f897/ijerph-19-00242-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ea2d/8751079/0a8165ede1d8/ijerph-19-00242-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ea2d/8751079/19cde518f897/ijerph-19-00242-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ea2d/8751079/0a8165ede1d8/ijerph-19-00242-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ea2d/8751079/19cde518f897/ijerph-19-00242-g002.jpg

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