2型糖尿病作为阿尔茨海默病的一个风险因素：综述与荟萃分析
Type 2 Diabetes Mellitus as a Risk Factor for Alzheimer's Disease: Review and Meta-Analysis.
作者信息
Athanasaki Athanasia, Melanis Konstantinos, Tsantzali Ioanna, Stefanou Maria Ioanna, Ntymenou Sofia, Paraskevas Sotirios G, Kalamatianos Theodosis, Boutati Eleni, Lambadiari Vaia, Voumvourakis Konstantinos I, Stranjalis George, Giannopoulos Sotirios, Tsivgoulis Georgios, Paraskevas George P
机构信息
Department of Neurology, Evangelismos Hospital, 10676 Athens, Greece.
2nd Department of Neurology, School of Medicine, National and Kapodistrian University of Athens, "Attikon" University General Hospital, 12462 Athens, Greece.
出版信息
Biomedicines. 2022 Mar 27;10(4):778. doi: 10.3390/biomedicines10040778.
Alzheimer's disease is the most common type of dementia, reaching 60-80% of case totals, and is one of the major global causes of the elderly population's decline in functionality concerning daily life activities. Epidemiological research has already indicated that, in addition to several others metabolic factors, diabetes mellitus type 2 is a risk factor of Alzheimer's disease. Many molecular pathways have been described, and at the same time, there are clues that suggest the connection between type 2 diabetes mellitus and Alzheimer's disease, through specific genes, autophagy, and even inflammatory pathways. A systematic review with meta-analysis was conducted, and its main goal was to reveal the multilevel connection between these diseases.
阿尔茨海默病是最常见的痴呆类型，占病例总数的60%-80%，是导致全球老年人口日常生活活动功能衰退的主要原因之一。流行病学研究已经表明，除了其他一些代谢因素外，2型糖尿病是阿尔茨海默病的一个风险因素。已经描述了许多分子途径，同时，有线索表明2型糖尿病与阿尔茨海默病之间通过特定基因、自噬甚至炎症途径存在联系。进行了一项系统评价和荟萃分析，其主要目的是揭示这些疾病之间的多层次联系。
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