Yoshida Makoto, Kobashi Yurie, Kawamura Takeshi, Shimazu Yuzo, Nishikawa Yoshitaka, Omata Fumiya, Zhao Tianchen, Yamamoto Chika, Kaneko Yudai, Nakayama Aya, Takita Morihito, Ito Naomi, Kawashima Moe, Sugiura Sota, Shibuya Kenji, Iwami Shingo, Kim Kwangsu, Iwanami Shoya, Kodama Tatsuhiko, Tsubokura Masaharu
Faculty of Medicine, Teikyo University School of Medicine, Itabashi Campus, Tokyo 173-8605, Japan.
Department of Radiation Health Management, Fukushima Medical University School of Medicine, Fukushima 960-1247, Japan.
Vaccines (Basel). 2022 Mar 26;10(4):515. doi: 10.3390/vaccines10040515.
This was a retrospective cohort study, which aimed to investigate the factors associated with hesitancy to receive a third dose of a coronavirus disease 2019 (COVID-19) vaccine. A paper-based questionnaire survey was administered to all participants. This study included participants who provided answers in the questionnaire about whether they had an intent to receive a third dose of a vaccine. Data on sex, age, area of residence, adverse reactions after the second vaccination, whether the third vaccination was desired, and reasons to accept or hesitate over the booster vaccination were retrieved. Among the 2439 participants, with a mean (±SD) age of 52.6 ± 18.9 years, and a median IgG-S antibody titer of 324.9 (AU/mL), 97.9% of participants indicated their intent to accept a third vaccination dose. The logistic regression revealed that participants of a younger age (OR = 0.98; 95% CI: 0.96-1.00) and with a higher antibody level (OR = 2.52; 95% CI: 1.27-4.99) were positively associated with hesitancy over the third vaccine. The efficacy of the COVID-19 vaccine and concerns about adverse reactions had a significant impact on behavior regarding the third vaccination. A rapid increase in the booster dose rate is needed to control the pandemic, and specific approaches should be taken with these groups that are likely to hesitate over the third vaccine, subsequently increasing booster contact rate.
这是一项回顾性队列研究，旨在调查与对2019冠状病毒病（COVID-19）第三剂疫苗接种犹豫相关的因素。对所有参与者进行了纸质问卷调查。本研究纳入了在问卷中回答是否有接种第三剂疫苗意愿的参与者。收集了有关性别、年龄、居住地区、第二次接种后的不良反应、是否希望接种第三剂疫苗以及对接种加强针疫苗接受或犹豫的原因的数据。在2439名参与者中，平均（±标准差）年龄为52.6±18.9岁，IgG-S抗体滴度中位数为324.9（AU/mL），97.9%的参与者表示愿意接受第三剂疫苗接种。逻辑回归显示，年龄较小的参与者（比值比=0.98；95%置信区间：0.96-1.00）和抗体水平较高的参与者（比值比=2.52；95%置信区间：1.27-4.99）与对第三剂疫苗的犹豫呈正相关。COVID-19疫苗的效力和对不良反应的担忧对第三剂疫苗接种行为有重大影响。需要迅速提高加强针接种率以控制疫情，并且应该针对那些可能对第三剂疫苗犹豫的群体采取特定方法，从而提高加强针接种率。
