Siemieniako-Werszko Agnieszka, Czupryna Piotr, Moniuszko-Malinowska Anna, Dunaj-Małyszko Justyna, Pancewicz Sławomir, Grygorczuk Sambor, Zajkowska Joanna
Department of Infectious Diseases and Neuroinfections, Medical University of Białystok, Żurawia 14, 15-540 Białystok, Poland.
Pathogens. 2022 Mar 29;11(4):416. doi: 10.3390/pathogens11040416.
Tick-borne encephalitis (TBE) is an emerging vector-borne disease in Europe caused by tick-borne encephalitis virus (TBEV), which belongs to Flaviviridae. Although most of the patients quickly recover from TBE, some require further neurological and psychiatric treatment due to persistent symptoms. The aim of the study was to evaluate the usefulness of an antibodies index for predicting the course of the disease and potential persistent sequalae. Sixty-six patients (49 males and 17 females, mean age 45.97 ± 13.69 years) with TBE hospitalized in the Department of Infectious Diseases and Neuroinfections, Medical University of Bialystok, Poland, in years 2016-2019 were included to the study. TBE antibodies titer in serum and CSF samples were measured with an Anti-TBEV ELISA (IgM, IgG) EUROIMMUN test. Patients who developed persistent sequelae after TBE had significantly lower IgG intrathecal index at admission. Additionally, IgG2/IgG1was significantly higher in patients who developed sequelae. IgG intrathecal index might be a useful tool for the prediction of TBE sequelae development.
蜱传脑炎（TBE）是欧洲一种新出现的媒介传播疾病，由蜱传脑炎病毒（TBEV）引起，该病毒属于黄病毒科。尽管大多数患者能迅速从蜱传脑炎中康复，但一些患者因症状持续需要进一步的神经和精神治疗。本研究的目的是评估抗体指数对预测疾病进程和潜在持续性后遗症的有用性。纳入了2016 - 2019年在波兰比亚韦斯托克医科大学传染病和神经感染科住院的66例蜱传脑炎患者（49例男性和17例女性，平均年龄45.97±13.69岁）。用抗TBEV ELISA（IgM、IgG）EUROIMMUN检测法测定血清和脑脊液样本中的蜱传脑炎抗体滴度。蜱传脑炎后出现持续性后遗症的患者入院时鞘内IgG指数显著较低。此外，出现后遗症的患者中IgG2/IgG1显著更高。鞘内IgG指数可能是预测蜱传脑炎后遗症发生的有用工具。
