Vong Long Binh, Nagasaki Yukio
School of Biomedical Engineering, International University, Ho Chi Minh 700000, Vietnam.
Vietnam National University Ho Chi Minh City (VNU-HCM), Ho Chi Minh 700000, Vietnam.
Antioxidants (Basel). 2020 Aug 26;9(9):791. doi: 10.3390/antiox9090791.
Nitric oxide (NO) plays important roles in various physiological and pathological functions and processes in the human body. Therapeutic application of NO molecules has been investigated in various diseases, including cardiovascular disease, cancer, and infections. However, the extremely short half-life of NO, which limits its clinical use considerably, along with non-specific distribution, has resulted in a low therapeutic index and undesired adverse effects. To overcome the drawbacks of using this gaseous signaling molecule, researchers in the last several decades have focused on innovative medical technologies, specifically nanoparticle-based drug delivery systems (DDSs), because these systems alter the biodistribution of the therapeutic agent through controlled release at the target tissues, resulting in a significant therapeutic drug effect. Thus, the application of nano-systems for NO delivery in the field of biomedicine, particularly in the development of new drugs for cancer treatment, has been increasing worldwide. In this review, we discuss NO delivery nanoparticle systems, with the aim of improving drug delivery development for conventional chemotherapies and controlling multidrug resistance in cancer treatments.
一氧化氮（NO）在人体各种生理和病理功能及过程中发挥着重要作用。人们已对NO分子在包括心血管疾病、癌症和感染在内的各种疾病中的治疗应用进行了研究。然而，NO极短的半衰期极大地限制了其临床应用，再加上其非特异性分布，导致治疗指数较低且出现不良副作用。为克服使用这种气体信号分子的缺点，在过去几十年中，研究人员专注于创新医疗技术，特别是基于纳米颗粒的药物递送系统（DDS），因为这些系统通过在靶组织处的控释改变治疗剂的生物分布，从而产生显著的治疗药物效果。因此，纳米系统在生物医学领域用于递送NO的应用，尤其是在开发用于癌症治疗的新药方面，在全球范围内一直在增加。在这篇综述中，我们讨论NO递送纳米颗粒系统，目的是改进传统化疗的药物递送开发并控制癌症治疗中的多药耐药性。
