槐耳多糖通过减少病毒吸附和进入来中断 PRV 感染。
Huaier Polysaccharide Interrupts PRV Infection via Reducing Virus Adsorption and Entry.
机构信息
Institutes of Agricultural Science and Technology Development, College of Veterinary Medicine, Yangzhou University, Yangzhou 225009, China.
Jiangsu Co-Innovation Center for Prevention and Control of Important Animal Infectious Diseases and Zoonoses, Yangzhou 225009, China.
出版信息
Viruses. 2022 Apr 1;14(4):745. doi: 10.3390/v14040745.
A pseudorabies virus (PRV) novel virulent variant outbreak occurred in China in 2011. However, little is known about PRV prevention and treatment. Huaier polysaccharide has been used to treat some solid cancers, although its antiviral activity has not been reported. Our study confirmed that the polysaccharide can effectively inhibit infection of PRV XJ5 in PK15 cells. It acted in a dose-dependent manner when blocking virus adsorption and entry into PK15 cells. Moreover, it suppressed PRV replication in PK15 cells. In addition, the results suggest that Huaier polysaccharide plays a role in treating PRV XJ5 infection by directly inactivating PRV XJ5. In conclusion, Huaier polysaccharide might be a novel therapeutic agent for preventing and controlling PRV infection.
2011 年中国暴发了伪狂犬病病毒（PRV）新型强毒变异株疫情。然而，对于 PRV 的防治却知之甚少。虽然已经有研究将槐耳多糖用于治疗某些实体瘤，但尚未有其抗病毒活性的报道。本研究证实槐耳多糖可有效抑制 PRV XJ5 在 PK15 细胞中的感染。该多糖通过阻止病毒吸附和进入 PK15 细胞，呈现出剂量依赖性抑制作用。此外，它还能抑制 PK15 细胞中的 PRV 复制。此外，研究结果提示槐耳多糖可能通过直接使 PRV XJ5 失活而在治疗 PRV XJ5 感染中发挥作用。总之，槐耳多糖可能成为预防和控制 PRV 感染的新型治疗药物。
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