Kashyap Dharambir, Mittal Sonam, Sak Katrin, Singhal Paavan, Tuli Hardeep Singh
Department of Medical Microbiology, Postgraduate Institute of Medical Education and Research (PGIMER), Chandigarh, Punjab, 160012, India.
School of Biotechnology, Jawaharlal Nehru University, New Delhi, 110067, India.
Tumour Biol. 2016 Oct;37(10):12927-12939. doi: 10.1007/s13277-016-5184-x. Epub 2016 Jul 22.
In the last few decades, the scientific community has discovered an immense potential of natural compounds in the treatment of dreadful diseases such as cancer. Besides the availability of a variety of natural bioactive molecules, efficacious cancer therapy still needs to be developed. So, to design an efficacious cancer treatment strategy, it is essential to understand the interactions of natural molecules with their respective cellular targets. Quercetin (Quer) is a naturally occurring flavonol present in many commonly consumed food items. It governs numerous intracellular targets, including the proteins involved in apoptosis, cell cycle, detoxification, antioxidant replication, and angiogenesis. The weight of available synergistic studies vigorously fortifies the utilization of Quer as a chemoprevention drug. This extensive review covers various therapeutic interactions of Quer with their recognized cellular targets involved in cancer treatment.
在过去几十年中，科学界发现天然化合物在治疗诸如癌症等可怕疾病方面具有巨大潜力。除了有多种天然生物活性分子外，仍需要开发有效的癌症治疗方法。因此，要设计一种有效的癌症治疗策略，了解天然分子与其各自细胞靶点之间的相互作用至关重要。槲皮素（Quer）是一种天然存在的黄酮醇，存在于许多常见的食用食品中。它控制着众多细胞内靶点，包括参与细胞凋亡、细胞周期、解毒、抗氧化复制和血管生成的蛋白质。现有协同研究的成果有力地支持了将槲皮素用作化学预防药物。这篇全面的综述涵盖了槲皮素与参与癌症治疗的公认细胞靶点之间的各种治疗相互作用。
