Division of Hematopathology, Department of Pathology, Anatomy, and Cell Biology, Sidney Kimmel Medical College, Thomas Jefferson University, Philadelphia, PA, USA.
Ann Lab Med. 2022 Sep 1;42(5):515-530. doi: 10.3343/alm.2022.42.5.515.
Automated hematology analyzers generate accurate complete blood counts (CBC) results on nearly all specimens. However, every laboratory encounters, at times, some specimens that yield no or inaccurate result(s) for one or more CBC parameters even when the analyzer is functioning properly and the manufacturer's instructions are followed to the letter. Inaccurate results, which may adversely affect patient care, are clinically unreliable and require the attention of laboratory professionals. Laboratory professionals must recognize unreliable results, determine the possible cause(s), and be acquainted with the ways to obtain reliable results on such specimens. We present a concise overview of the known causes of unreliable automated CBC results, ways to recognize them, and means commonly utilized to obtain reliable results. Some examples of unreliable automated CBC results are also illustrated. Pertinent analyzer-specific information can be found in the manufacturers' operating manuals.
自动化血液分析仪几乎可以对所有标本生成准确的全血细胞计数（CBC）结果。然而，每个实验室有时都会遇到一些标本，即使分析仪正常运行且严格按照制造商的说明操作，也会出现一个或多个 CBC 参数无结果或结果不准确的情况。这些不准确的结果可能会对患者护理产生不利影响，在临床上不可靠，需要实验室专业人员的关注。实验室专业人员必须识别不可靠的结果，确定可能的原因，并熟悉在这些标本上获得可靠结果的方法。我们简要概述了导致自动化 CBC 结果不可靠的已知原因、识别方法以及获得可靠结果的常用方法。还举例说明了一些不可靠的自动化 CBC 结果。有关特定于分析仪的信息可以在制造商的操作手册中找到。
