Kharbikar Bhushan N, Zhong Justin X, Cuylear Darnell L, Perez Cynthia A, Desai Tejal A
Department of Bioengineering and Therapeutic Sciences, University of California, San Francisco, San Francisco, CA, USA.
UC Berkeley - UCSF Graduate Program in Bioengineering, San Francisco, CA, USA.
Curr Opin Biomed Eng. 2021 Sep;19. doi: 10.1016/j.cobme.2021.100299. Epub 2021 May 26.
Tissue engineering strategies, notably biomaterials, can be modularly designed and tuned to match specific patient needs. Although many challenges within tissue engineering remain, the incorporation of diagnostic strategies to create theranostic (combined therapy and diagnostic) biomaterials presents a unique platform to provide dual monitoring and treatment capabilities and advance the field toward personalized technologies. In this review, we summarize recent developments in this young field of regenerative theranostics and discuss the clinical potential and outlook of these systems from a tissue engineering perspective. As the need for precision and personalized medicines continues to increase to address diseases in all tissues in a patient-specific manner, we envision that such theranostic platforms can serve these needs.
组织工程策略，尤其是生物材料，可以进行模块化设计和调整以满足特定患者的需求。尽管组织工程领域仍存在许多挑战，但将诊断策略纳入以创建治疗诊断（治疗与诊断相结合）生物材料，提供了一个独特的平台，可实现双重监测和治疗功能，并推动该领域向个性化技术发展。在本综述中，我们总结了这个新兴的再生治疗诊断领域的最新进展，并从组织工程的角度讨论了这些系统的临床潜力和前景。随着对精准和个性化药物的需求持续增长，以患者特定的方式解决所有组织中的疾病，我们设想这样的治疗诊断平台可以满足这些需求。
