内皮细胞中的线粒体转移与血管健康
Mitochondrial transfer in endothelial cells and vascular health.
作者信息
Im Gwang-Bum, Melero-Martin Juan M
机构信息
Department of Cardiac Surgery, Boston Children's Hospital, Boston, MA 02115, USA; Department of Surgery, Harvard Medical School, Boston, MA 02115, USA.
Department of Cardiac Surgery, Boston Children's Hospital, Boston, MA 02115, USA; Department of Surgery, Harvard Medical School, Boston, MA 02115, USA; Harvard Stem Cell Institute, Cambridge, MA 02138, USA.
出版信息
Trends Cell Biol. 2025 May 13. doi: 10.1016/j.tcb.2025.04.004.
Mitochondria play a vital role in cellular energy metabolism and vascular health, with their function directly influencing endothelial cell (EC) bioenergetics and integrity. Mitochondrial transfer has emerged as a key mechanism of intercellular communication, impacting angiogenesis, tissue repair, and cellular homeostasis. This review highlights recent findings on mitochondrial transfer, including natural mechanisms - such as tunneling nanotubes (TNTs) and extracellular vesicles (EVs) - and artificial approaches like mitochondrial transplantation. These processes enhance EC function and support vascularization under pathological conditions, including ischemia. While early clinical trials demonstrate therapeutic potential, challenges such as mitochondrial instability and scaling host-derived mitochondria persist. Continued research is essential to optimize mitochondrial transfer and advance its application as a therapeutic strategy for restoring vascular health.
线粒体在细胞能量代谢和血管健康中起着至关重要的作用，其功能直接影响内皮细胞（EC）的生物能量学和完整性。线粒体转移已成为细胞间通讯的关键机制，影响血管生成、组织修复和细胞稳态。本综述重点介绍了线粒体转移的最新研究成果，包括自然机制——如隧道纳米管（TNTs）和细胞外囊泡（EVs）——以及线粒体移植等人工方法。这些过程可增强内皮细胞功能，并在包括缺血在内的病理条件下支持血管生成。虽然早期临床试验显示出治疗潜力，但线粒体不稳定性和扩大宿主来源线粒体等挑战依然存在。持续的研究对于优化线粒体转移并推动其作为恢复血管健康的治疗策略的应用至关重要。
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