Department of Urology, UCSF.
Departments of Nutrition & Epidemiology, Harvard T.H. Chan School of Public Health, Boston, MA, USA.
BJU Int. 2022 Oct;130(4):514-521. doi: 10.1111/bju.15765. Epub 2022 Jun 9.
To evaluate the longitudinal association between plant-based diet index (PDI) score and incident erectile dysfunction (ED).
We conducted a prospective analysis of 21 942 men aged 40 to 75 years who were enrolled in the Health Professionals Follow-Up Study. ED was assessed with questionnaires every 4 years starting in 2000. Dietary data were collected via validated food frequency questionnaires completed every 4 years and were used to calculate total PDI scores, as well as healthy (hPDI) and unhealthy (uPDI) subscores. Multivariable Cox proportional hazards models were used to compute hazard ratios (HRs) for incident ED. All models were stratified by age (<60, 60 to <70, ≥70 years).
Among men aged 60 to <70 years, hPDI was inversely associated with incident ED. Those in the highest quintile of hPDI in that age group had an 18% lower risk of ED (HR 0.82, 95% confidence interval (CI) 0.73-0.91; P-trend <0.001) compared to those in the lowest quintile. Conversely, uPDI was positively associated with ED in men aged <60 years (HR 1.27, 95% CI 1.01-1.60; P-trend = 0.02).
Encouraging a healthy plant-based diet may be an environmentally sustainable intervention for men interested in maintaining erectile function.
评估植物性饮食指数（PDI）评分与勃起功能障碍（ED）发病之间的纵向关联。
我们对 21942 名年龄在 40 至 75 岁的男性进行了前瞻性分析，这些男性均参加了健康专业人员随访研究。从 2000 年开始，通过问卷每 4 年评估一次 ED。通过每 4 年完成的验证后的食物频率问卷收集饮食数据，并用于计算总 PDI 评分以及健康（hPDI）和不健康（uPDI）亚评分。使用多变量 Cox 比例风险模型计算 ED 发病的风险比（HR）。所有模型均按年龄（<60 岁、60-<70 岁、≥70 岁）分层。
在年龄在 60-<70 岁的男性中，hPDI 与 ED 发病呈负相关。在该年龄组中，hPDI 得分最高的五分位数男性发生 ED 的风险降低 18%（HR 0.82，95%置信区间（CI）0.73-0.91；P 趋势 <0.001），而得分最低的五分位数男性则相反。相反，在年龄<60 岁的男性中，uPDI 与 ED 发病呈正相关（HR 1.27，95%CI 1.01-1.60；P 趋势=0.02）。
鼓励健康的植物性饮食可能是对有兴趣维持勃起功能的男性具有环境可持续性的干预措施。
