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Induction of SARS-CoV-2 neutralizing antibodies by CoronaVac and BNT162b2 vaccines in naïve and previously infected individuals.科兴新冠疫苗（CoronaVac）和BNT162b2疫苗在未感染和既往感染个体中诱导产生严重急性呼吸综合征冠状病毒2（SARS-CoV-2）中和抗体的情况。
EBioMedicine. 2022 Apr;78:103972. doi: 10.1016/j.ebiom.2022.103972. Epub 2022 Mar 30.
2
Evaluation of Immunogenicity by Pseudovirus Neutralization Assays for SARS-CoV-2 Variants after Primary and Booster Immunization.评价 SARS-CoV-2 变异株在初次免疫和加强免疫后，基于假病毒中和试验的免疫原性。
Int J Infect Dis. 2022 Apr;117:97-102. doi: 10.1016/j.ijid.2022.01.068. Epub 2022 Feb 2.
3
The T cell immune response against SARS-CoV-2.针对 SARS-CoV-2 的 T 细胞免疫应答。
Nat Immunol. 2022 Feb;23(2):186-193. doi: 10.1038/s41590-021-01122-w. Epub 2022 Feb 1.
4
Heterologous versus homologous COVID-19 booster vaccination in previous recipients of two doses of CoronaVac COVID-19 vaccine in Brazil (RHH-001): a phase 4, non-inferiority, single blind, randomised study.巴西两剂科兴新冠疫苗（CoronaVac）既往接种者中异源与同源加强接种 COVID-19 疫苗（RHH-001）：一项四期、非劣效性、单盲、随机研究。
Lancet. 2022 Feb 5;399(10324):521-529. doi: 10.1016/S0140-6736(22)00094-0. Epub 2022 Jan 21.
5
Comparison of the immunogenicity of BNT162b2 and CoronaVac COVID-19 vaccines in Hong Kong.比较香港科兴和国药新冠疫苗的免疫原性。
Respirology. 2022 Apr;27(4):301-310. doi: 10.1111/resp.14191. Epub 2021 Nov 24.
6
Neutralising antibody titres as predictors of protection against SARS-CoV-2 variants and the impact of boosting: a meta-analysis.中和抗体滴度作为预测对 SARS-CoV-2 变异体的保护作用以及加强免疫的影响的指标：一项荟萃分析。
Lancet Microbe. 2022 Jan;3(1):e52-e61. doi: 10.1016/S2666-5247(21)00267-6. Epub 2021 Nov 15.
7
A phase III, observer-blind, randomized, placebo-controlled study of the efficacy, safety, and immunogenicity of SARS-CoV-2 inactivated vaccine in healthy adults aged 18-59 years: An interim analysis in Indonesia.一项在 18-59 岁健康成年人中评估 SARS-CoV-2 灭活疫苗的有效性、安全性和免疫原性的 III 期、观察者盲法、随机、安慰剂对照研究：印度尼西亚的中期分析。
Vaccine. 2021 Oct 22;39(44):6520-6528. doi: 10.1016/j.vaccine.2021.09.052. Epub 2021 Sep 24.
8
Efficacy and safety of an inactivated whole-virion SARS-CoV-2 vaccine (CoronaVac): interim results of a double-blind, randomised, placebo-controlled, phase 3 trial in Turkey.一种灭活全病毒 SARS-CoV-2 疫苗（克尔来福）的有效性和安全性：在土耳其进行的一项双盲、随机、安慰剂对照、3 期临床试验的中期结果。
Lancet. 2021 Jul 17;398(10296):213-222. doi: 10.1016/S0140-6736(21)01429-X. Epub 2021 Jul 8.
9
Effectiveness of an Inactivated SARS-CoV-2 Vaccine in Chile.智利开展的灭活 SARS-CoV-2 疫苗有效性研究
N Engl J Med. 2021 Sep 2;385(10):875-884. doi: 10.1056/NEJMoa2107715. Epub 2021 Jul 7.
10
Neutralizing antibody levels are highly predictive of immune protection from symptomatic SARS-CoV-2 infection.中和抗体水平高度预测对有症状的 SARS-CoV-2 感染的免疫保护作用。
Nat Med. 2021 Jul;27(7):1205-1211. doi: 10.1038/s41591-021-01377-8. Epub 2021 May 17.

Predicting the efficacy of new coronavirus vaccines - Are neutralising antibodies enough?

作者信息

Miller Elizabeth

机构信息

FMedSci, Department of Infectious Disease Epidemiology, Faculty of Epidemiology and Public Health, London School of Hygiene & Tropical Medicine, Keppel Street, London WC1E 7HT, UK.

出版信息

EBioMedicine. 2022 May;79:104034. doi: 10.1016/j.ebiom.2022.104034. Epub 2022 Apr 27.

DOI:10.1016/j.ebiom.2022.104034
PMID:35489231
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9044976/
Abstract
摘要