Xi Juqun, Zhang Jingjing, Qian Xiaodong, An Lanfang, Fan Lei
Institute of Translational Medicine, Department of Pharmacology, School of Medicine, Yangzhou University Yangzhou Jiangsu 225001 China.
Jiangsu Key Laboratory of Integrated Traditional Chinese and Western Medicine for Prevention and Treatment of Senile Diseases Yangzhou Jiangsu 225001 China.
RSC Adv. 2020 Jan 3;10(2):909-913. doi: 10.1039/c9ra09343e. eCollection 2020 Jan 2.
Here, we develop a visible light-triggered platform to activate the biomimetic activity of CuS nanoparticles by incorporating a photoacid generator. Under visible-light illumination, the remarkable pH decrease, caused by the intramolecular photoreaction of the photoacid generator, activates the peroxidase-like activity of the CuS nanoparticles. This visible light-triggered pH switch meets the antibacterial demands of peroxidase mimics perfectly in bacteria-infected wounds. Importantly, the built-in torches of mobile phones are able to replace the visible-light source to activate the peroxidase-mimicking activity of CuS nanoparticles to combat bacteria, which greatly promotes the utility and adaptability of this antibacterial platform.
在此，我们开发了一个可见光触发平台，通过引入光酸发生器来激活硫化铜纳米颗粒的仿生活性。在可见光照射下，光酸发生器的分子内光反应导致显著的pH值下降，从而激活了硫化铜纳米颗粒的过氧化物酶样活性。这种可见光触发的pH开关在细菌感染伤口中完美地满足了过氧化物酶模拟物的抗菌需求。重要的是，手机的内置手电筒能够替代可见光源来激活硫化铜纳米颗粒的过氧化物酶模拟活性以对抗细菌，这极大地提高了该抗菌平台的实用性和适应性。
