Dighriri Ibrahim M, Alhusayni Khaled M, Mobarki Ahmed Y, Aljerary Ibrahim S, Alqurashi Khalid A, Aljuaid Fai A, Alamri Khalid A, Mutwalli Abeer A, Maashi Nada A, Aljohani Alwaleed M, Alqarni Abdulrahman M, Alfaqih Athbah E, Moazam Sumiya M, Almutairi Muath N, Almutairi Afnan N
Department of Pharmacy, King Abdulaziz Specialist Hospital, Taif, SAU.
Department of Medical Laboratory, The Regional Laboratory and the Central Blood Bank, Abha, SAU.
Cureus. 2022 Mar 26;14(3):e23526. doi: 10.7759/cureus.23526. eCollection 2022 Mar.
Vaccinations prevented severe clinical complications of COVID-19. It was considered a vital component of living endemically with COVID-19. The Pfizer-BioNTech vaccine is the first mRNA-based vaccination that enhances immunity. Resulting in various adverse effects that may emerge after vaccination. This systematic review was undertaken to assess the Pfizer-BioNTech vaccine side effects by reviewing the previous studies. A total of 107 PubMed and Google Scholar publications were screened for Pfizer-BioNTech COVID-19 vaccine side effects. Fourteen articles met the study inclusion criteria. The included searching terms were a combination of "Pfizer vaccine and Side effects," "BioNTech vaccine and side effects," and "BNT162b2 vaccine and side effects," as well as all synonyms. The total number of participants in the 14 studies was 10,632 participants. Average of the most frequent side effects of 14 studies were injection site pain 77.34%, fatigue 43%, muscle pain 39.67%, local swelling 33.57%, headache 33.27%, joint pain 25.75%, chills 18.34%, fever 18%, itching 9.38%, lymph nodes swelling 7.86%, nausea 7.58%, dyspnea 7.86%,and diarrhea 6.36%. The average side effects after the first dose were 79% compared with 84% after the second dose. The average occurs side effects in females at 69.8% compared with males 30.2%. Our study reveals that side effects after the Pfizer-BioNTech vaccine are common, but they are usually mild and self-limited. Local reactions like pain at the injection site are the most common. Anaphylactic shock or severe reactions are rare. We hope that our results will reassure the public that the benefits of vaccination far exceed the dangers. Also, help reduce vaccine hesitancy among individuals worried about vaccine safety and possible adverse effects.
疫苗接种预防了新冠病毒病（COVID-19）的严重临床并发症。它被认为是与COVID-19地方流行共存的重要组成部分。辉瑞-BioNTech疫苗是第一种增强免疫力的基于信使核糖核酸（mRNA）的疫苗。接种后可能会出现各种不良反应。本系统评价旨在通过回顾既往研究来评估辉瑞-BioNTech疫苗的副作用。共筛选了107篇来自PubMed和谷歌学术的关于辉瑞-BioNTech新冠疫苗副作用的出版物。14篇文章符合研究纳入标准。纳入的检索词包括“辉瑞疫苗和副作用”、“BioNTech疫苗和副作用”、“BNT162b2疫苗和副作用”以及所有同义词。14项研究的参与者总数为10632人。14项研究中最常见副作用的平均发生率分别为：注射部位疼痛77.34%、疲劳43%、肌肉疼痛39.67%、局部肿胀33.57%、头痛33.27%、关节疼痛25.75%、寒战18.34%、发热18%、瘙痒9.38%、淋巴结肿大7.86%、恶心7.58%、呼吸困难7.86%、腹泻6.36%。第一剂后的平均副作用发生率为79%，第二剂后为84%。女性出现副作用的平均发生率为69.8%，男性为30.2%。我们的研究表明，辉瑞-BioNTech疫苗接种后的副作用很常见，但通常较轻且为自限性。注射部位疼痛等局部反应最为常见。过敏性休克或严重反应很少见。我们希望我们的结果能让公众放心，接种疫苗的益处远大于风险。同时，有助于减少担心疫苗安全性和可能不良反应的人群中的疫苗犹豫情绪。
