Tajik Somayeh, Beitollahi Hadi, Aflatoonian Mohammad Reza, Mohtat Bita, Aflatoonian Behnaz, Shoaie Iran Sheikh, Khalilzadeh Mohammad A, Ziasistani Marzieh, Zhang Kaiqiang, Jang Ho Won, Shokouhimehr Mohammadreza
Neuroscience Research Center, Kerman University of Medical Sciences Kerman Iran
Research Center for Tropical and Infectious Diseases, Kerman University of Medical Sciences Kerman Iran.
RSC Adv. 2020 Apr 17;10(26):15171-15178. doi: 10.1039/d0ra02380a. eCollection 2020 Apr 16.
The present investigation examines a sensitive electrochemical technique to detect desipramine through FeO/CuO nanoparticles (NPs). FeO/CuO NPs were synthesized a coprecipitation procedure, and the products were characterized energy disperse spectroscopy, X-ray diffraction, transmission electron microscopy, scanning electron microscopy, and vibrating sample magnetometer. The voltage-current curve and differential pulse voltammetry examinations of FeO/CuO-modified screen-printed electrode (FeO/CuO/SPE) were followed by the determination of electro-catalytic activities toward desipramine oxidation in a phosphate buffer solution (pH = 7.0). In addition, the value of diffusion coefficient ( = 3.0 × 10 cm s) for desipramine was calculated. Then, based on the optimum conditions, it was observed that the currents of the oxidation peak were linearly proportionate to the concentration of desipramine in the broad range between 0.08 and 400.0 μM and LOD of 0.03 μM (S/N = 3). Finally, our new sensor was successfully utilized to detect desipramine in the real samples, with reasonable recovery in the range of 97.2% to 102.7%.
本研究考察了一种通过FeO/CuO纳米颗粒（NPs）检测地昔帕明的灵敏电化学技术。采用共沉淀法合成FeO/CuO NPs，并通过能谱分析、X射线衍射、透射电子显微镜、扫描电子显微镜和振动样品磁强计对产物进行表征。在测定FeO/CuO修饰的丝网印刷电极（FeO/CuO/SPE）的电压-电流曲线和差分脉冲伏安法后，考察其在磷酸盐缓冲溶液（pH = 7.0）中对去甲丙咪嗪氧化的电催化活性。此外，还计算了地昔帕明的扩散系数值（ = 3.0 × 10 cm s）。然后，在最佳条件下，观察到氧化峰电流与地昔帕明浓度在0.08至400.0 μM的宽范围内呈线性比例，检测限为0.03 μM（S/N = 3）。最后，我们的新型传感器成功用于检测实际样品中的地昔帕明，回收率在97.2%至102.7%之间，结果合理。
