伴有焦虑或抑郁症状的青少年体内维生素B12、叶酸、同型半胱氨酸、炎症介质（白细胞介素-6、肿瘤坏死因子-α和C反应蛋白）水平
Vitamin B12, Folate, Homocysteine, Inflammatory Mediators (Interleukin-6, Tumor Necrosis Factor-α and C-Reactive Protein) Levels in Adolescents with Anxiety or Depressive Symptoms.
作者信息
Tan Yongjun, Zhou Li, Huang Jiagui, Chen Xia, Wu Youlin, Song Xiaosong, Wang Jiani, Hu Hua, Yang Qin
机构信息
Department of Neurology, The First Affiliated Hospital of Chongqing Medical University, Chongqing, People's Republic of China.
Department of Psychiatry, The First Affiliated Hospital of Chongqing Medical University, Chongqing, People's Republic of China.
出版信息
Neuropsychiatr Dis Treat. 2023 Apr 7;19:785-800. doi: 10.2147/NDT.S399378. eCollection 2023.
PURPOSE
To evaluate the prevalence of abnormal vitamin B12, folate, total homocysteine (tHcy), interleukin-6 (IL-6), tumor necrosis factor-α (TNF-α), C-reactive protein (CRP) levels, to analyze the relationship between these parameters and the severity of anxiety or depressive symptoms, and to explore the possible factors associated with abnormal levels of these parameters in adolescents with anxiety or depressive symptoms.
METHODS
Adolescent (aged 12-18 years) outpatients with anxiety or depressive symptoms were recruited. The patient health questionnaire-9 and generalized anxiety disorder scale-7 were used to measure the severity of depression and anxiety. Serum vitamin B12, folate, tHcy, IL-6, TNF-α, and CRP levels were determined.
RESULTS
128 subjects were recruited. The prevalence of vitamin B12 and folate deficiency, tHcy, TNF-α, IL-6, and CRP elevation was 8.6%, 10.2%, 25.8%, 14.8%, 21.9%, and 10.2%, respectively, in adolescents with anxiety or depressive symptoms. Lower vitamin B12 levels were correlated with a higher risk of severe anxiety and depressive symptoms. The severity of some symptoms of anxiety or depression were weakly correlated with vitamin B12, folate, tHcy, IL-6, and CRP levels. Vitamin B12, folate, and tHcy levels were not associated with inflammatory mediators. Vitamin B12 deficiency was associated with older age and higher tHcy levels. Folate deficiency was associated with elevated tHcy. Elevated tHcy was associated with lower vitamin B12 and folate levels. IL-6 elevation was associated with elevated CRP and TNF-α. CRP elevation was associated with older age, higher BMI, and current drinking.
CONCLUSION
Lower vitamin B12 levels were correlated with a higher risk of severe anxiety or depressive symptoms. Weak correlations were observed between the severity of some symptoms of anxiety or depression and vitamin B12, folate, tHcy, IL-6, and CRP levels. Vitamin B12, folate, and tHcy levels were related to each other. IL-6 elevation was associated with elevated CRP and TNF-α. CRP elevation was associated with older age, higher BMI, and current drinking.
目的
评估维生素B12、叶酸、总同型半胱氨酸（tHcy）、白细胞介素-6（IL-6）、肿瘤坏死因子-α（TNF-α）、C反应蛋白（CRP）水平异常的患病率，分析这些参数与焦虑或抑郁症状严重程度之间的关系，并探讨焦虑或抑郁症状青少年中这些参数水平异常的可能相关因素。
方法
招募有焦虑或抑郁症状的青少年（12至18岁）门诊患者。使用患者健康问卷-9和广泛性焦虑障碍量表-7来测量抑郁和焦虑的严重程度。测定血清维生素B12、叶酸、tHcy、IL-6、TNF-α和CRP水平。
结果
共招募了128名受试者。有焦虑或抑郁症状的青少年中，维生素B12和叶酸缺乏、tHcy、TNF-α、IL-6和CRP升高的患病率分别为8.6%、10.2%、25.8%、14.8%、21.9%和10.2%。较低的维生素B12水平与严重焦虑和抑郁症状的较高风险相关。焦虑或抑郁的某些症状的严重程度与维生素B12、叶酸、tHcy、IL-6和CRP水平呈弱相关。维生素B12、叶酸和tHcy水平与炎症介质无关。维生素B12缺乏与年龄较大和tHcy水平较高相关。叶酸缺乏与tHcy升高相关。tHcy升高与较低的维生素B12和叶酸水平相关。IL-6升高与CRP和TNF-α升高相关。CRP升高与年龄较大、BMI较高和当前饮酒相关。
结论
较低的维生素B12水平与严重焦虑或抑郁症状的较高风险相关。焦虑或抑郁的某些症状的严重程度与维生素B12、叶酸、tHcy、IL-6和CRP水平之间存在弱相关性。维生素B12、叶酸和tHcy水平相互关联。IL-6升高与CRP和TNF-α升高相关。CRP升高与年龄较大、BMI较高和当前饮酒相关。
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