Kazemi Youkabed, Dehghani Sadegh, Nosrati Rahim, Taghdisi Seyed Mohammad, Abnous Khalil, Alibolandi Mona, Ramezani Mohammad
Pharmaceutical Research Center, Pharmaceutical Technology Institute, Mashhad University of Medical Sciences, Mashhad, Iran; Department of Pharmaceutical Biotechnology, School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran.
Pharmaceutical Research Center, Pharmaceutical Technology Institute, Mashhad University of Medical Sciences, Mashhad, Iran.
Life Sci. 2022 Jul 1;300:120593. doi: 10.1016/j.lfs.2022.120593. Epub 2022 Apr 29.
CD44 is a cell matrix adhesion molecule overexpressed on the cell surfaces of the major cancers. CD44 as a cancer-related biomarker has an essential role in the invasion and metastasis of cancer. The detection and quantification of CD44 can provide essential information useful for clinical cancer diagnosis. In this regard, biosensors with sensitive and specific properties, give prominence to the development of CD44 detection platforms. To date, various aptamer-based sensitive-enhancers together with nanoparticles (NPs) have been combined into the biosensors systems to provide an innovative biosensing method (aptasensors/nano-aptasensors) with substantially improved detection limit. This review article discusses the recent advances in the field of biosensors, nanobiosensors, and aptasensors for the quantitative determination of CD44 and the detection of CD44-expressing cancer cells.
CD44是一种在主要癌症细胞表面过度表达的细胞基质粘附分子。CD44作为一种癌症相关生物标志物，在癌症的侵袭和转移中起着至关重要的作用。CD44的检测和定量可为临床癌症诊断提供有用的重要信息。在这方面，具有灵敏和特异特性的生物传感器突出了CD44检测平台的发展。迄今为止，各种基于适配体的敏感增强剂与纳米颗粒（NPs）已被组合到生物传感器系统中，以提供一种检测限大幅提高的创新生物传感方法（适配体传感器/纳米适配体传感器）。这篇综述文章讨论了用于定量测定CD44和检测表达CD44的癌细胞的生物传感器、纳米生物传感器和适配体传感器领域的最新进展。
