Education and Development Center of Medical Sciences, Ministry of Health & Medical Education, Iran.
Functional Neurosurgery Research Center, Shohada Tajrish Comprehensive Neurosurgical Center of Excellence, Shahid Beheshti University of Medical Sciences, Tehran, Iran; Department of Pharmacology and Toxicology, School of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran.
J Pharm Biomed Anal. 2022 Mar 20;211:114624. doi: 10.1016/j.jpba.2022.114624. Epub 2022 Jan 29.
Acute myocardial infarction (AMI) is one of the main health problems, leading to a major rate of mortality and morbidity. Given that myoglobin (Mb) is the earliest rising biomarker after AMI, recent studies have shown that Mb may be considered as a suitable biomarker for the detection of cardiac damage. Recently, aptamer-based biosensors (aptasensors) have attracted special attention for being accessible and their capability for sensitive detection of Mb. Moreover, the nano-aptasensors have provided new advances toward accurate detection of Mb. In this review, we provide an outline of the various types of optical and electrochemical-based aptasensors that have been developed for determination of Mb-related AMI. We also summarized recent developments in the applications of nano-aptasensors for recognition of Mb as an AMI biomarker. Future perspectives and challenges of aptamer-based Mb detection are discussed in brief as well.
急性心肌梗死（AMI）是主要的健康问题之一，导致高死亡率和发病率。鉴于肌红蛋白（Mb）是 AMI 后最早升高的生物标志物，最近的研究表明，Mb 可被视为检测心脏损伤的合适生物标志物。最近，基于适体的生物传感器（aptasensors）因其易于获得和对 Mb 的敏感检测能力而受到特别关注。此外，纳米 aptasensors 为 Mb 的准确检测提供了新的进展。在这篇综述中，我们概述了为测定与 Mb 相关的 AMI 而开发的各种基于光学和电化学的 aptasensors。我们还总结了纳米 aptasensors 在识别 Mb 作为 AMI 生物标志物方面的最新应用进展。简要讨论了基于适体的 Mb 检测的未来展望和挑战。
