Sanders M E, Kopicky J A, Wigley F M, Shin M L, Frank M M, Joiner K A
J Rheumatol. 1986 Dec;13(6):1028-34.
Rheumatoid and osteoarthritic synovial membranes were examined for evidence of terminal complement pathway activation. Using antiserum highly specific for C9 neoantigen, immunofluorescent microscopy was employed to study synovial membrane specimens from 4 patients with rheumatoid arthritis, one patient with psoriatic arthritis, and 5 patients with osteoarthritis. C9 neoantigen was detected in 3 of the 4 rheumatoid membranes, the one psoriatic membrane, and one of the 5 osteoarthritic membranes. Activation of the terminal pathway of complement through C9 should be added to the spectrum of immunologic events known to occur in some rheumatoid synovial membranes.
对类风湿性关节炎和骨关节炎的滑膜进行检查，以寻找终末补体途径激活的证据。使用对C9新抗原具有高度特异性的抗血清，采用免疫荧光显微镜技术研究了4例类风湿性关节炎患者、1例银屑病关节炎患者和5例骨关节炎患者的滑膜标本。在4例类风湿性滑膜中的3例、1例银屑病滑膜以及5例骨关节炎滑膜中的1例中检测到了C9新抗原。补体终末途径通过C9的激活应被添加到已知在某些类风湿性滑膜中发生的免疫事件谱中。
