Chair and Department of Inorganic and Analytical Chemistry, Poznan University of Medical Sciences, Rokietnicka 3, 60-806, Poznan, Poland.
Doctoral School, Poznan University of Medical Sciences, Bukowska 70, 60-812, Poznan, Poland.
ChemMedChem. 2022 Jul 5;17(13):e202200185. doi: 10.1002/cmdc.202200185. Epub 2022 May 23.
Photodynamic and sonodynamic therapy are therapies having great potential in the treatment of bacterial infections and cancer. Their background is associated with photo- and sonosensitizers - substances that can be excited when exposed to light or ultrasound. These sensitizers belong to a various groups of compound, including porphyrins, porphyrazines, and phthalocyanines. Releasing the energy when returning to the ground state can occur in the manner of transferring it to oxygen molecules, leading to reactive oxygen species able to disrupt membranes of bacterial and cancer cells, leaving the organism's cells unaffected. In recent years, the number of reports on numerous sensitizers being effective has been constantly growing. Therefore, the development of this field may prove beneficial for dealing with cancer and microbes. This review describes the development of photodynamic and sonodynamic therapy, as well as their combination, with emphasis on sonodynamic therapy and its potential in the treatment of cancer and bacterial infections.
光动力和声动力疗法在治疗细菌感染和癌症方面具有巨大的潜力。它们的背景与光和声敏剂有关——这些敏化剂是在暴露于光或超声时可以被激发的物质。这些敏化剂属于各种化合物群体，包括卟啉、卟嗪和酞菁。当回到基态时，能量可以通过将其转移到氧分子的方式释放，从而产生能够破坏细菌和癌细胞膜的活性氧物种，而使生物体的细胞不受影响。近年来，关于许多敏化剂有效的报告数量不断增加。因此，这一领域的发展可能有助于治疗癌症和微生物。本综述描述了光动力和声动力疗法的发展，以及它们的结合，重点介绍了声动力疗法及其在癌症和细菌感染治疗中的潜力。
