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Deregulated JAK3 mediates growth advantage and hemophagocytosis in extranodal nasal-type natural killer/T-cell lymphoma.

作者信息

Picod Adrien, Martino Suella, Cervera Pascale, Manuceau Gregory, Arca Marc, Wittner Monica, Zhang YanYan, Liang He, Beghi Florian, Solary Eric, Louache Fawzia, Coppo Paul

机构信息

Inserm U1287, Gustave Roussy, 94805 Villejuif.

Service d'Anatomopathologie, AP-HP - Sorbonne Université.

出版信息

Haematologica. 2022 Sep 1;107(9):2218-2225. doi: 10.3324/haematol.2021.280349.

DOI:10.3324/haematol.2021.280349
PMID:35511669
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9425324/
Abstract
摘要
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/db42/9425324/a9a7b5de10f6/1072218.fig3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/db42/9425324/fbe93ac1da4d/1072218.fig1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/db42/9425324/8e11b1bbea88/1072218.fig2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/db42/9425324/a9a7b5de10f6/1072218.fig3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/db42/9425324/fbe93ac1da4d/1072218.fig1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/db42/9425324/8e11b1bbea88/1072218.fig2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/db42/9425324/a9a7b5de10f6/1072218.fig3.jpg

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本文引用的文献

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NK-/T-cell lymphomas.NK/T 细胞淋巴瘤。
Leukemia. 2021 Sep;35(9):2460-2468. doi: 10.1038/s41375-021-01313-2. Epub 2021 Jun 11.
2
A comprehensive analysis of Lymphoma-associated haemophagocytic syndrome in a large French multicentre cohort detects some clues to improve prognosis.一项针对大型法国多中心队列中淋巴瘤相关噬血细胞综合征的综合分析发现了一些改善预后的线索。
Br J Haematol. 2018 Oct;183(1):68-75. doi: 10.1111/bjh.15506. Epub 2018 Jul 24.
3
Novel JAK3-Activating Mutations in Extranodal NK/T-Cell Lymphoma, Nasal Type.结外 NK/T 细胞淋巴瘤，鼻型中的新型 JAK3 激活突变。
Am J Pathol. 2017 May;187(5):980-986. doi: 10.1016/j.ajpath.2017.01.004. Epub 2017 Mar 9.
4
Clinical features and survival of extranodal natural killer/T cell lymphoma with and without hemophagocytic syndrome.伴有和不伴有噬血细胞综合征的结外自然杀伤/T细胞淋巴瘤的临床特征与生存情况
Ann Hematol. 2016 Dec;95(12):2023-2031. doi: 10.1007/s00277-016-2805-9. Epub 2016 Sep 6.
5
Genetic alterations of JAK/STAT cascade and histone modification in extranodal NK/T-cell lymphoma nasal type.鼻型结外NK/T细胞淋巴瘤中JAK/STAT级联反应的基因改变与组蛋白修饰
Oncotarget. 2015 Jul 10;6(19):17764-76. doi: 10.18632/oncotarget.3776.
6
Development and validation of the HScore, a score for the diagnosis of reactive hemophagocytic syndrome.HScore 的制定与验证：一种用于诊断反应性噬血细胞综合征的评分系统。
Arthritis Rheumatol. 2014 Sep;66(9):2613-20. doi: 10.1002/art.38690.
7
JAK3 deregulation by activating mutations confers invasive growth advantage in extranodal nasal-type natural killer cell lymphoma.激活突变导致 JAK3 失调，赋予结外鼻型自然杀伤细胞淋巴瘤侵袭性生长优势。
Leukemia. 2014 Feb;28(2):338-48. doi: 10.1038/leu.2013.157. Epub 2013 May 21.
8
Interferon-γ and granulocyte/monocyte colony-stimulating factor production by natural killer cells involves different signaling pathways and the adaptor stimulator of interferon genes (STING).自然杀伤细胞产生干扰素-γ和粒细胞/巨噬细胞集落刺激因子涉及不同的信号通路和干扰素基因刺激物（STING）衔接蛋白。
J Biol Chem. 2013 Apr 12;288(15):10715-21. doi: 10.1074/jbc.M112.435602. Epub 2013 Feb 26.
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Janus kinase 3-activating mutations identified in natural killer/T-cell lymphoma.自然杀伤/T 细胞淋巴瘤中鉴定出的 Janus 激酶 3 激活突变。
Cancer Discov. 2012 Jul;2(7):591-7. doi: 10.1158/2159-8290.CD-12-0028. Epub 2012 Jun 15.
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Hemophagocytosis causes a consumptive anemia of inflammation.噬血细胞可引起炎症消耗性贫血。
J Exp Med. 2011 Jun 6;208(6):1203-14. doi: 10.1084/jem.20102538. Epub 2011 May 30.