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基因特征分析和一种含有源自 2009 年大流行 H1N1 病毒内部基因片段的欧亚类禽 H1N1 猪流感病毒的致病性研究。

Genetic characterization and pathogenicity of a reassortant Eurasian avian-like H1N1 swine influenza virus containing an internal gene cassette from 2009 pandemic H1N1 virus.

机构信息

Shanghai Veterinary Research Institute, Chinese Academy of Agricultural Sciences, No.518, Ziyue Road, Minhang District, Shanghai, 200241, China.

Shanghai Veterinary Research Institute, Chinese Academy of Agricultural Sciences, No.518, Ziyue Road, Minhang District, Shanghai, 200241, China; Jiangsu Co-innovation Center for Prevention and Control of Important Animal Infectious Diseases and Zoonoses, Yangzhou, 225009, China.

出版信息

Virol Sin. 2022 Aug;37(4):627-630. doi: 10.1016/j.virs.2022.04.009. Epub 2022 May 2.

DOI:10.1016/j.virs.2022.04.009
PMID:35513274
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9437529/
Abstract

• Identification of a reassortant EA H1N1 SIV (SD/18) which isolated from a pig farm in Shandong, north China. • Phylogenetic analysis showed that SD/18 virus containing a complete internal gene cassette from pdm/09 virus. • The results of pathogenicity in mice showed that the mortality rate of SD/18 virus in mice could reach 100%.

摘要

• 鉴定一株分离自中国北方山东省某猪场的重配型 EA H1N1 SIV（SD/18）。• 系统进化分析显示，SD/18 病毒含有源自 pdm/09 病毒的完整内部基因片段。• 小鼠致病性研究结果表明，SD/18 病毒在小鼠中的致死率可达 100%。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/583b/9437529/5f4a5fb7f2fb/gr1a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/583b/9437529/5f4a5fb7f2fb/gr1a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/583b/9437529/5f4a5fb7f2fb/gr1a.jpg

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