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环状RNA SMARCA5通过靶向miR-346/FBXL2轴抑制胃癌进展。

Circular RNA SMARCA5 inhibits gastric cancer progression through targeting the miR-346/ FBXL2 axis.

作者信息

Li Quanying, Tang Hongna, Hu Fangfang, Qin Changjiang

机构信息

Department of General Surgery, Huaihe Hospital of Henan University No. 8 of Baobei Road Kaifeng 475000 China

出版信息

RSC Adv. 2019 Jun 10;9(32):18277-18284. doi: 10.1039/c9ra02230a.

DOI:10.1039/c9ra02230a
PMID:35515212
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9064680/
Abstract

Circular RNA (circRNA) SMARCA5 (circSMARCA5) is a cancer-related circRNA that has been observed to be involved in the progression of several types of cancer. However, the role of circSMARCA5 in gastric cancer has not been reported. In the present study, we aimed to explore the function and mechanism of circSMARCA5 in gastric cancer. Our results showed that circSMARCA5 expression was significantly decreased in human gastric cancer tissues and cell lines. Further investigations demonstrated that overexpression of circSMARCA5 in SGC7901 cells inhibited cell proliferation, migration and invasion. Luciferase reporter assays proved that circSMARCA5 acted as a sponge for miroRNA-346 (miR-346) and regulated the expression of F-Box and leucine rich repeat protein 2 (FBXL2). Furthermore, transfection of miR-346 mimics into cells overexpressing circSMARCA5 blocked the function of circSMARCA5. Finally, we found that knockdown FBXL2 significantly reversed the effects of miR-346 inhibitor on gastric cell proliferation, migration and invasion. Collectively, circSMARCA5 exhibited a tumor suppressor-like activity in gastric cancer regulating the miR-346/FBXL2 axis.

摘要

环状RNA（circRNA）SMARCA5（circSMARCA5）是一种与癌症相关的circRNA，已观察到其参与多种癌症的进展。然而，circSMARCA5在胃癌中的作用尚未见报道。在本研究中，我们旨在探讨circSMARCA5在胃癌中的功能和机制。我们的结果表明，circSMARCA5在人胃癌组织和细胞系中的表达显著降低。进一步研究表明，在SGC7901细胞中过表达circSMARCA5可抑制细胞增殖、迁移和侵袭。荧光素酶报告基因检测证明，circSMARCA5作为微小RNA-346（miR-346）的海绵，调节F-Box和富含亮氨酸重复蛋白2（FBXL2）的表达。此外，将miR-346模拟物转染到过表达circSMARCA5的细胞中可阻断circSMARCA5的功能。最后，我们发现敲低FBXL2可显著逆转miR-346抑制剂对胃癌细胞增殖、迁移和侵袭的影响。总之，circSMARCA5在胃癌中表现出类似肿瘤抑制的活性，调节miR-346/FBXL2轴。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bfc1/9064680/017561b659ef/c9ra02230a-f4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bfc1/9064680/020c895b5792/c9ra02230a-f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bfc1/9064680/2674ae8c5cbc/c9ra02230a-f2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bfc1/9064680/a81a94809d40/c9ra02230a-f3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bfc1/9064680/017561b659ef/c9ra02230a-f4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bfc1/9064680/020c895b5792/c9ra02230a-f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bfc1/9064680/2674ae8c5cbc/c9ra02230a-f2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bfc1/9064680/a81a94809d40/c9ra02230a-f3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bfc1/9064680/017561b659ef/c9ra02230a-f4.jpg

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3
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Appl Biochem Biotechnol. 2024 Apr;196(4):1863-1875. doi: 10.1007/s12010-023-04645-0. Epub 2023 Jul 13.
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Roles of hypoxic environment and M2 macrophage-derived extracellular vesicles on the progression of non-small cell lung cancer.缺氧微环境及 M2 巨噬细胞衍生细胞外囊泡在非小细胞肺癌进展中的作用。
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