Zhu Yi, Huang Gaozhen, Li Shihao, Xiong Hong, Chen Ruiqi, Zuo Ling, Liu Hongwei
Department of Urology, Affiliated Hospital of Guangdong Medical University, Zhanjiang, China.
Department of Traditional Chinese Medicine, The Second Affiliated Hospital of Guangdong Medical University, Zhanjiang, China.
Front Genet. 2022 Aug 23;13:921306. doi: 10.3389/fgene.2022.921306. eCollection 2022.
Circular RNAs (circRNAs) are recognized as a novel type of single-stranded endogenous noncoding RNA molecule with the characteristics of tissue specificity, sequence conservation and structural stability. Accumulating studies have shown that circRNAs play a unique biological role in different kinds of diseases. CircRNAs can affect tumor proliferation, migration, metastasis and other behaviors by modulating the expression of downstream genes. CircSMARCA5, an example of a circRNA, is dysregulated in various noninfectious diseases, such as tumors, osteoporosis, atherosclerosis and coronary heart disease. Furthermore, recent studies have demonstrated that circSMARCA5 is associated with the occurrence and development of a variety of tumors, including gastric cancer, glioblastoma, hepatocellular carcinoma, multiple myeloma, colorectal cancer, breast cancer and osteosarcoma. Mechanistically, circSMARCA5 primarily acts as a sponge of miRNAs to regulate the expression of downstream genes, and can serve as a potential biomarker for the diagnosis of malignant tumors. This review summarizes the biological roles of circSMARCA5 and its molecular mechanism of action in various diseases. Moreover, the meta-analysis of some publications showed that the expression of circSMARCA5 was significantly correlated with the prognosis of patients and tumor TNM stage, showing that circSMARCA5 has the potential to be a prognostic marker.
环状RNA（circRNAs）被认为是一种新型的单链内源性非编码RNA分子，具有组织特异性、序列保守性和结构稳定性等特征。越来越多的研究表明，circRNAs在各种疾病中发挥着独特的生物学作用。CircRNAs可通过调节下游基因的表达来影响肿瘤增殖、迁移、转移等行为。CircSMARCA5作为circRNAs的一个例子，在各种非感染性疾病中表达失调，如肿瘤、骨质疏松症、动脉粥样硬化和冠心病。此外，最近的研究表明，circSMARCA5与多种肿瘤的发生和发展有关，包括胃癌、胶质母细胞瘤、肝细胞癌、多发性骨髓瘤、结直肠癌、乳腺癌和骨肉瘤。从机制上讲，circSMARCA5主要作为miRNAs的海绵来调节下游基因的表达，并可作为诊断恶性肿瘤的潜在生物标志物。本综述总结了circSMARCA5在各种疾病中的生物学作用及其分子作用机制。此外，对一些出版物的荟萃分析表明，circSMARCA5的表达与患者预后和肿瘤TNM分期显著相关，表明circSMARCA5有潜力成为一种预后标志物。
