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用于生物医学应用的Ti6Al4V表面的选择性改性。

Selective modification of Ti6Al4V surfaces for biomedical applications.

作者信息

Rodriguez Gabriela Melo, Bowen James, Zelzer Mischa, Stamboulis Artemis

机构信息

Biomaterials Group, School of Metallurgy and Materials, University of Birmingham Edgbaston Birmingham B15 2TT UK

School of Engineering and Innovation, The Open University Walton Hall Milton Keynes MK7 6AA UK.

出版信息

RSC Adv. 2020 May 6;10(30):17642-17652. doi: 10.1039/c9ra11000c. eCollection 2020 May 5.

DOI:10.1039/c9ra11000c
PMID:35515604
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9053614/
Abstract

The surface of a medical implant is required to interact favourably with ions, biomolecules and cells , commonly resulting in the formation of the extracellular matrix. Medical grade Ti6Al4V alloy is widely used in orthopaedic and dental applications for bone replacement due to its advantageous mechanical properties and biocompatibility, which enhances the adhesion between native tissue and the implanted material. In this study, chemical and thermal modification of a medical-grade Ti6Al4V alloy were performed to enhance electrostatic interactions at the alloy surface with a synthetic peptide, suitable for conferring drug release capabilities and antimicrobial properties. The modified surfaces exhibited a range of topographies and chemical compositions depending primarily on the treatment temperature. The surface wetting behaviour was found to be pH-dependent, as were the adhesive properties, evidenced by chemical force titration atomic force microscopy.

摘要

医用植入物的表面需要与离子、生物分子和细胞良好地相互作用，这通常会导致细胞外基质的形成。医用级Ti6Al4V合金因其有利的机械性能和生物相容性而广泛应用于骨科和牙科的骨替代应用中，这种生物相容性增强了天然组织与植入材料之间的粘附力。在本研究中，对医用级Ti6Al4V合金进行了化学和热改性，以增强合金表面与合成肽之间的静电相互作用，该合成肽适用于赋予药物释放能力和抗菌性能。改性表面呈现出一系列主要取决于处理温度的形貌和化学成分。发现表面润湿行为和粘附性能都与pH值有关，化学力滴定原子力显微镜证明了这一点。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/61e8/9053614/2ef277586d72/c9ra11000c-f10.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/61e8/9053614/ea8699acec38/c9ra11000c-f1.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/61e8/9053614/ecc4d1f24560/c9ra11000c-f4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/61e8/9053614/3516bb05a9e2/c9ra11000c-f5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/61e8/9053614/4a1a57159fe4/c9ra11000c-f6.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/61e8/9053614/42536090becf/c9ra11000c-f7.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/61e8/9053614/e0c333bb5109/c9ra11000c-f8.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/61e8/9053614/1f64e6e56e4e/c9ra11000c-f9.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/61e8/9053614/2ef277586d72/c9ra11000c-f10.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/61e8/9053614/ea8699acec38/c9ra11000c-f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/61e8/9053614/dfc40ac830b7/c9ra11000c-f2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/61e8/9053614/58e2081b2e54/c9ra11000c-f3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/61e8/9053614/ecc4d1f24560/c9ra11000c-f4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/61e8/9053614/3516bb05a9e2/c9ra11000c-f5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/61e8/9053614/4a1a57159fe4/c9ra11000c-f6.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/61e8/9053614/42536090becf/c9ra11000c-f7.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/61e8/9053614/e0c333bb5109/c9ra11000c-f8.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/61e8/9053614/1f64e6e56e4e/c9ra11000c-f9.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/61e8/9053614/2ef277586d72/c9ra11000c-f10.jpg

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