Passaretti Paolo, Sun Yiwei, Dafforn Timothy R, Oppenheimer Pola Goldberg
Institute of Cancer and Genomic Science, University of Birmingham Birmingham B15 2TT UK
School of Engineering and Materials Science, Queen Mary University of London London E1 4NS UK.
RSC Adv. 2020 Jul 3;10(42):25385-25392. doi: 10.1039/d0ra04086j. eCollection 2020 Jun 29.
To truly understand the mechanisms behind the supramolecular self-assembly of nanocomponents, the characterisation of their surface properties is crucial. M13 emerged as a practical nanocomponent for bio-nanoassemblies of functional materials and devices, and its popularity is increasing as time goes by. The investigation performed in this study provides important information about the surface charge and the surface area of M13 determined through the comparison of structural data and the measurement of -potential at pH ranging between 2 and 11. The developed methodologies along with the experimental findings can be subsequently exploited as a novel and convenient prediction tool of the total charge of modified versions of M13. This, in turn, will facilitate the design of the self-assembly strategies which would combine the virus building block with other micro and nano components intermolecular interactions.
要真正理解纳米组件超分子自组装背后的机制，表征其表面性质至关重要。M13作为功能材料和器件生物纳米组装的实用纳米组件应运而生，并且随着时间的推移其受欢迎程度不断提高。本研究中进行的调查通过比较结构数据以及测量pH值在2至11之间的ζ电位，提供了有关M13表面电荷和表面积的重要信息。所开发的方法以及实验结果随后可作为预测M13修饰版本总电荷的新颖便捷工具。反过来，这将有助于设计自组装策略，将病毒构建块与其他微米和纳米组件通过分子间相互作用结合起来。
