Aly Arafa H, Mohamed Doaa, A Mohaseb Mona, El-Gawaad N S Abd, Trabelsi Y
TH-PPM Group, Physics Department, Beni-Suef University Beni Suef Egypt
Department of Physics, Faculty of Applied Science, Umm-Al-Qura University Mecca Saudi Arabia.
RSC Adv. 2020 Aug 27;10(53):31765-31772. doi: 10.1039/d0ra05448h. eCollection 2020 Aug 26.
A new biophotonic sensor based on photonic crystal (PC) has been designed for the detection of creatinine concentration in blood, and is considered an important small molecule biomarker of renal dysfunction. Based on the transfer matrix method (TMM), we theoretically investigated the transmittance spectra of a one dimensional alternating dielectric photonic crystal (PC) designed as (AB)//(AB) made of MgF (A), CeO (B) and creatinine concentration present in blood (). The transmission spectra exhibit resonant peaks within the photonic band gap (PBG) indicative of so-called defect modes, which depend on parameters, such as concentration of creatinine in blood, thickness of defect layer and incident angle. The proposed sensor can determine the physiological levels of creatinine in human blood serum samples. The estimated parameters realize an efficient biophotonic sensor wherein sensitivity was tuned from 136.4 nm per RIU to 306.25 nm per RIU and is very useful for the detection of creatinine.
一种基于光子晶体（PC）的新型生物光子传感器已被设计用于检测血液中的肌酐浓度，肌酐被认为是肾功能障碍的一种重要小分子生物标志物。基于转移矩阵法（TMM），我们从理论上研究了一种一维交替介质光子晶体（PC）的透射光谱，该光子晶体设计为（AB）//（AB），由MgF（A）、CeO（B）以及血液中存在的肌酐浓度组成。透射光谱在光子带隙（PBG）内呈现出共振峰，这表明存在所谓的缺陷模式，这些模式取决于诸如血液中肌酐浓度、缺陷层厚度和入射角等参数。所提出的传感器能够测定人血清样本中肌酐的生理水平。所估计的参数实现了一种高效的生物光子传感器，其灵敏度从每折射率单位（RIU）136.4纳米调整到每RIU 306.25纳米，对肌酐的检测非常有用。
