Meza Rodrigo C, Ancatén-González Carlos, Chiu Chiayu Q, Chávez Andrés E
Centro Interdisciplinario de Neurociencia de Valparaíso (CINV), Instituto de Neurociencias, Universidad de Valparaíso, Valparaíso, Chile.
Programa de Doctorado en Ciencias, Mención Neurociencia, Universidad de Valparaíso, Valparaíso, Chile.
Front Cell Neurosci. 2022 Apr 18;16:864828. doi: 10.3389/fncel.2022.864828. eCollection 2022.
The transient receptor potential vanilloid 1 (TRPV1), a ligand-gated nonselective cation channel, is well known for mediating heat and pain sensation in the periphery. Increasing evidence suggests that TRPV1 is also expressed at various central synapses, where it plays a role in different types of activity-dependent synaptic changes. Although its precise localizations remain a matter of debate, TRPV1 has been shown to modulate both neurotransmitter release at presynaptic terminals and synaptic efficacy in postsynaptic compartments. In addition to being required in these forms of synaptic plasticity, TRPV1 can also modify the inducibility of other types of plasticity. Here, we highlight current evidence of the potential roles for TRPV1 in regulating synaptic function in various brain regions, with an emphasis on principal mechanisms underlying TRPV1-mediated synaptic plasticity and metaplasticity. Finally, we discuss the putative contributions of TRPV1 in diverse brain disorders in order to expedite the development of next-generation therapeutic treatments.
瞬时受体电位香草酸亚型1（TRPV1）是一种配体门控的非选择性阳离子通道，在外周介导热觉和痛觉方面广为人知。越来越多的证据表明，TRPV1也在各种中枢突触中表达，在不同类型的活动依赖性突触变化中发挥作用。尽管其确切定位仍存在争议，但TRPV1已被证明可调节突触前终末的神经递质释放以及突触后区室的突触效能。除了在这些形式的突触可塑性中发挥作用外，TRPV1还可以改变其他类型可塑性的诱导性。在这里，我们重点介绍TRPV1在调节不同脑区突触功能方面潜在作用的当前证据，重点关注TRPV1介导的突触可塑性和元可塑性的主要机制。最后，我们讨论TRPV1在各种脑部疾病中的假定作用，以加速下一代治疗方法的开发。
