基于磁热效应的无创聚焦磁刺激用于慢性卒中治疗中的功能恢复
Magnetothermal-based non-invasive focused magnetic stimulation for functional recovery in chronic stroke treatment.
作者信息
Kim Hohyeon, Kim Jihye, Kim Jahae, Oh Seungjun, Choi Kangho, Yoon Jungwon
机构信息
School of Integrated Technology, Gwangju Institute of Science and Technology, Gwangju, 61005, South Korea.
Department of Neurology, Chonnam National University Hospital and Medical School, 8 Hak-dong, Dong-gu, Gwangju, 501-757, South Korea.
出版信息
Sci Rep. 2023 Mar 27;13(1):4988. doi: 10.1038/s41598-023-31979-w.
Magnetic heat-based brain stimulation of specific lesions could promote the restoration of impaired motor function caused by chronic stroke. We delivered localized stimulation by nanoparticle-mediated heat generation within the targeted brain area via focused magnetic stimulation. The middle cerebral artery occlusion model was prepared, and functional recovery in the chronic-phase stroke rat model was demonstrated by the therapeutic application of focused magnetic stimulation. We observed a transient increase in blood-brain barrier permeability at the target site of < 4 mm and metabolic brain activation at the target lesion. After focused magnetic stimulation, the rotarod score increased by 390 ± 28% (p < 0.05) compared to the control group. Standardized uptake value in the focused magnetic stimulation group increased by 2063 ± 748% (p < 0.01) compared to the control group. Moreover, an increase by 24 ± 5% (p < 0.05) was observed in the sham group as well. Our results show that non-invasive focused magnetic stimulation can safely modulate BBB permeability and enhance neural activation for chronic-phase stroke treatment in the targeted deep brain area.
基于磁热的特定脑损伤刺激可促进慢性中风所致运动功能障碍的恢复。我们通过聚焦磁刺激在目标脑区内通过纳米颗粒介导产热来进行局部刺激。制备了大脑中动脉闭塞模型，并通过聚焦磁刺激的治疗应用证明了慢性期中风大鼠模型的功能恢复。我们观察到在小于4毫米的目标部位血脑屏障通透性短暂增加，以及目标损伤部位脑代谢激活。聚焦磁刺激后，与对照组相比，转棒试验评分增加了390±28%（p<0.05）。聚焦磁刺激组的标准化摄取值与对照组相比增加了2063±748%（p<0.01）。此外，假手术组也观察到增加了24±5%（p<0.05）。我们的结果表明，非侵入性聚焦磁刺激可安全调节血脑屏障通透性，并增强靶向深部脑区慢性期中风治疗的神经激活。
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