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Magnetothermal-based non-invasive focused magnetic stimulation for functional recovery in chronic stroke treatment.

作者信息

Kim Hohyeon, Kim Jihye, Kim Jahae, Oh Seungjun, Choi Kangho, Yoon Jungwon

机构信息

School of Integrated Technology, Gwangju Institute of Science and Technology, Gwangju, 61005, South Korea.

Department of Neurology, Chonnam National University Hospital and Medical School, 8 Hak-dong, Dong-gu, Gwangju, 501-757, South Korea.

出版信息

Sci Rep. 2023 Mar 27;13(1):4988. doi: 10.1038/s41598-023-31979-w.

DOI:10.1038/s41598-023-31979-w
PMID:36973390
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10042827/
Abstract

Magnetic heat-based brain stimulation of specific lesions could promote the restoration of impaired motor function caused by chronic stroke. We delivered localized stimulation by nanoparticle-mediated heat generation within the targeted brain area via focused magnetic stimulation. The middle cerebral artery occlusion model was prepared, and functional recovery in the chronic-phase stroke rat model was demonstrated by the therapeutic application of focused magnetic stimulation. We observed a transient increase in blood-brain barrier permeability at the target site of < 4 mm and metabolic brain activation at the target lesion. After focused magnetic stimulation, the rotarod score increased by 390 ± 28% (p < 0.05) compared to the control group. Standardized uptake value in the focused magnetic stimulation group increased by 2063 ± 748% (p < 0.01) compared to the control group. Moreover, an increase by 24 ± 5% (p < 0.05) was observed in the sham group as well. Our results show that non-invasive focused magnetic stimulation can safely modulate BBB permeability and enhance neural activation for chronic-phase stroke treatment in the targeted deep brain area.

摘要
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e94a/10042827/e7a4c1ed42b0/41598_2023_31979_Fig9_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e94a/10042827/4a1b1f19d32a/41598_2023_31979_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e94a/10042827/6b5c4dfaffc1/41598_2023_31979_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e94a/10042827/33e6d2067d31/41598_2023_31979_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e94a/10042827/71f780946a92/41598_2023_31979_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e94a/10042827/5a2e1bea551d/41598_2023_31979_Fig5_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e94a/10042827/c3fd7d0984ed/41598_2023_31979_Fig6_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e94a/10042827/3cfad8a33931/41598_2023_31979_Fig7_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e94a/10042827/0e923dcba634/41598_2023_31979_Fig8_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e94a/10042827/e7a4c1ed42b0/41598_2023_31979_Fig9_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e94a/10042827/4a1b1f19d32a/41598_2023_31979_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e94a/10042827/6b5c4dfaffc1/41598_2023_31979_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e94a/10042827/33e6d2067d31/41598_2023_31979_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e94a/10042827/71f780946a92/41598_2023_31979_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e94a/10042827/5a2e1bea551d/41598_2023_31979_Fig5_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e94a/10042827/c3fd7d0984ed/41598_2023_31979_Fig6_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e94a/10042827/3cfad8a33931/41598_2023_31979_Fig7_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e94a/10042827/0e923dcba634/41598_2023_31979_Fig8_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e94a/10042827/e7a4c1ed42b0/41598_2023_31979_Fig9_HTML.jpg

相似文献

[1]
Magnetothermal-based non-invasive focused magnetic stimulation for functional recovery in chronic stroke treatment.

Sci Rep. 2023-3-27

[2]
Focused magnetic stimulation for motor recovery after stroke.

Brain Stimul. 2024

[3]
MicroRNA-149-5p regulates blood-brain barrier permeability after transient middle cerebral artery occlusion in rats by targeting S1PR2 of pericytes.

FASEB J. 2018-1-18

[4]
An In Vivo Mouse Model to Study Blood-Brain Barrier Destabilization in the Chronic Phase of Stroke.

Methods Mol Biol. 2022

[5]
Direct stimulation of angiotensin II type 2 receptor initiated after stroke ameliorates ischemic brain damage.

Am J Hypertens. 2014-8

[6]
Mitochondrial crisis in cerebrovascular endothelial cells opens the blood-brain barrier.

Stroke. 2015-6

[7]
Sema3E/PlexinD1 inhibition is a therapeutic strategy for improving cerebral perfusion and restoring functional loss after stroke in aged rats.

Neurobiol Aging. 2018-6-11

[8]
Claudin-1-Dependent Destabilization of the Blood-Brain Barrier in Chronic Stroke.

J Neurosci. 2018-11-30

[9]
Safety and efficacy of transcranial direct current stimulation in acute experimental ischemic stroke.

Stroke. 2013-8-27

[10]
Notoginsenoside R1 intervenes degradation and redistribution of tight junctions to ameliorate blood-brain barrier permeability by Caveolin-1/MMP2/9 pathway after acute ischemic stroke.

Phytomedicine. 2021-9

引用本文的文献

[1]
Localized brain stimulation with mild magnetic hyperthermia promotes microglia activity towards reactive and autophagic phenotypes in vivo.

Sci Rep. 2025-7-8

[2]
Advances in magnetic field approaches for non-invasive targeting neuromodulation.

Front Hum Neurosci. 2025-4-28

[3]
Cellular Activity Modulation Mediated by Near Infrared-Irradiated Polydopamine Nanoparticles: In Vitro and Ex Vivo Investigation.

ACS Nano. 2025-5-6

[4]
Microfabrication Technologies for Nanoinvasive and High-Resolution Magnetic Neuromodulation.

Adv Sci (Weinh). 2024-12

本文引用的文献

[1]
Transient Receptor Potential Vanilloid 1 Function at Central Synapses in Health and Disease.

Front Cell Neurosci. 2022-4-18

[2]
Dodging blood brain barrier with "nano" warriors: Novel strategy against ischemic stroke.

Theranostics. 2022

[3]
Pennes' bioheat equation vs. porous media approach in computer modeling of radiofrequency tumor ablation.

Sci Rep. 2021-3-5

[4]
Application of low-intensity pulsed therapeutic ultrasound on mesenchymal precursors does not affect their cell properties.

PLoS One. 2021

[5]
Bimanual motor skill learning and robotic assistance for chronic hemiparetic stroke: a randomized controlled trial.

Neural Regen Res. 2021-8

[6]
The role of astrocyte-mediated plasticity in neural circuit development and function.

Neural Dev. 2021-1-7

[7]
Transcranial pulse current stimulation improves the locomotor function in a rat model of stroke.

Neural Regen Res. 2021-7

[8]
Neural Stimulation and Molecular Mechanisms of Plasticity and Regeneration: A Review.

Front Cell Neurosci. 2020-10-14

[9]
Engineering Core-Shell Structures of Magnetic Ferrite Nanoparticles for High Hyperthermia Performance.

Nanomaterials (Basel). 2020-5-21

[10]
Acute neuromodulation restores spinally-induced motor responses after severe spinal cord injury.

Exp Neurol. 2020-2-11

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