Kalantzis Spyridon, Veziroglu Salih, Kohlhaas Theresa, Flörke Christian, Mishra Yogendra Kumar, Wiltfang Jörg, Açil Yahya, Faupel Franz, Aktas Oral Cenk, Gülses Aydin
Department of Oral and Maxillofacial Surgery, University Hospital of Schleswig-Holstein Campus Kiel, Arnold-Heller-Straße 3 24105 Kiel Germany
Chair for Multicomponent Materials, Institute for Materials Science, Faculty of Engineering, Kiel University Kaiserstr. 2 24143 Kiel Germany
RSC Adv. 2020 Aug 5;10(48):28935-28940. doi: 10.1039/d0ra05141a. eCollection 2020 Aug 3.
Titanium alloys are the most commonly used dental and orthopedic implant materials due to their proven biocompatibility and mechanical properties. The native oxide layer (TiO layer) formed on such Ti-based implants acts as the self-protecting layer against possible ion release. Increasing the oxide layer thickness further on such TiO implants even opens the triggering of the osseointegration process if the oxide layer is having a certain degree of roughness, preferably higher. This work reports a novel photocatalytic patterning of sputter deposited TiO layers with flower-like Au structures to enhance the early osteoblastic activity. The prepared hierarchical Au structures, composed of micro- and nanoscale features on the top, lead to improved number of filopodia formation. This suggest that proposed Au-TiO surface may foster the cell attachment and as well as cell proliferation.
钛合金因其已被证实的生物相容性和机械性能，是最常用的牙科和骨科植入材料。在这种基于钛的植入物上形成的天然氧化层（TiO层）作为防止可能的离子释放的自我保护层。如果氧化层具有一定程度的粗糙度，最好是更高的粗糙度，在这种TiO植入物上进一步增加氧化层厚度甚至会开启骨整合过程的触发。这项工作报道了一种用花状金结构对溅射沉积的TiO层进行新型光催化图案化处理，以增强早期成骨细胞活性。所制备的分层金结构由顶部的微米级和纳米级特征组成，导致丝状伪足形成数量增加。这表明所提出的金 - TiO表面可能促进细胞附着以及细胞增殖。
