Reali Savannah, Najib Elias Y, Treuerné Balázs Krisztina E, Chern Hui Tan Adeline, Váradi Linda, Hibbs David E, Groundwater Paul W
The University of Sydney School of Pharmacy, Camperdown Campus Sydney NSW 2006 Australia.
CSIRO Manufacturing Normanby Road Clayton VIC 3168 Australia
RSC Adv. 2019 Jul 10;9(37):21486-21497. doi: 10.1039/c9ra03118a. eCollection 2019 Jul 5.
In addition to limiting the effectiveness of antimicrobial agents, antimicrobial resistance (AMR) is a significant global health concern as it is responsible for significant mortality/morbidity and increased economic burdens on healthcare systems. Diagnostic tests have been suggested as a means of prolonging the effectiveness of current antimicrobials; culture and other conventional diagnostics are hindered in their practicality as they are time- and labour intensive to perform. Point-of-care (POC) testing is performed near where the patient is being treated and can provide timely results that allow evidence based clinical interventions to be made. This review aims to outline the chemical principles behind some novel and emerging diagnostic techniques which have the required speed, simplicity, effectiveness and low-cost for incorporation into POC devices which can be used to inform and optimize antimicrobial use.
除了限制抗菌药物的有效性外，抗菌药物耐药性（AMR）还是一个重大的全球健康问题，因为它会导致大量的死亡/发病，并增加医疗系统的经济负担。诊断测试被认为是延长现有抗菌药物有效性的一种手段；培养和其他传统诊断方法在实际应用中受到阻碍，因为它们执行起来既耗时又费力。即时检测（POC）在患者接受治疗的地点附近进行，可以提供及时的结果，以便进行基于证据的临床干预。本综述旨在概述一些新颖且正在兴起的诊断技术背后的化学原理，这些技术具备所需的速度、简便性、有效性和低成本，可纳入POC设备，用于指导和优化抗菌药物的使用。
