Department of Molecular, Cellular and Developmental Biology, Yale University, New Haven, CT 06520, USA.
J Cell Sci. 2022 May 1;135(9). doi: 10.1242/jcs.259579. Epub 2022 May 6.
The study of how neighboring tissues physically interact with each other, inter-tissue adhesion, is an emerging field at the interface of cell biology, biophysics and developmental biology. Inter-tissue adhesion can be mediated by either cell-extracellular matrix adhesion or cell-cell adhesion, and both the mechanisms and consequences of inter-tissue adhesion have been studied in vivo in numerous vertebrate and invertebrate species. In this Review, we discuss recent progress in understanding the many functions of inter-tissue adhesion in development and evolution. Inter-tissue adhesion can couple the motion of adjacent tissues, be the source of mechanical resistance that constrains morphogenesis, and transmit tension required for normal development. Tissue-tissue adhesion can also create mechanical instability that leads to tissue folding or looping. Transient inter-tissue adhesion can facilitate tissue invasion, and weak tissue adhesion can generate friction that shapes and positions tissues within the embryo. Lastly, we review studies that reveal how inter-tissue adhesion contributes to the diversification of animal morphologies.
相邻组织之间的物理相互作用的研究，即组织间黏附，是细胞生物学、生物物理学和发育生物学交叉领域的一个新兴领域。组织间黏附可以通过细胞-细胞外基质黏附或细胞-细胞黏附来介导，并且在许多脊椎动物和无脊椎动物物种中，已经在体内研究了组织间黏附的机制和后果。在这篇综述中，我们讨论了在理解组织间黏附在发育和进化中的许多功能方面的最新进展。组织间黏附可以使相邻组织的运动耦联，成为限制形态发生的机械阻力的来源，并传递正常发育所需的张力。组织-组织黏附也可以产生导致组织折叠或成环的机械不稳定性。短暂的组织间黏附可以促进组织侵袭，而较弱的组织黏附可以产生摩擦力，从而塑造和定位胚胎内的组织。最后，我们回顾了揭示组织间黏附如何促进动物形态多样化的研究。
