Department of Breast and Thyroid Surgery, The Affiliated Nanhua Hospital, Hengyang Medical School, University of South China, Hengyang, China.
Department of Hand & Microsurgery, The Affiliated Nanhua Hospital, Hengyang Medical School, University of South China, Hengyang, China.
J Clin Lab Anal. 2022 Jun;36(6):e24473. doi: 10.1002/jcla.24473. Epub 2022 May 6.
Thyroid dysfunction is a common thyroid disorder in our life and its symptoms are non-specific, therefore the diagnosis of thyroid dysfunction is important for patients. Albumin (ALB) can carry thyroid hormones to their sites of action as a way to achieve rapid delivery of thyroid hormones to the tissues. The purpose of this study was to investigate the relationship between serum ALB levels and total triiodothyronine (TT3) in adults.
Data from the 2007-2012 National Health and Nutrition Examination Survey (NHANES) were used to examine the association between ALB and TT3 using multivariate logistic regression models. Fitting smoothed curves and generalized weighted models were also used.
The analysis included a total of 7933 participants that we found an independent positive relationship between ALB and TT3 among participants [0.006 (0.003, 0.009)]. In men, there was a significant positive correlation between ALB and TT3, whereas in women ALB and TT3 suggested a significant negative correlation. Moreover, our study revealed that the independent association between the levels of ALB and TT3 was significant in Non-Hispanic White, but not in Non-Hispanic Black. Notably, we found a U-shaped association between ALB and serum TT3 in total participants (inflection point for ALB: 41 g/L) and females after adjusted covariates (inflection point for ALB: 46 g/L).
We found a U-shaped relationship between serum ALB and TT3 with infection point at 41 g/L for ALB, which may provide a reference for future screening in adults with thyroid dysfunction.
甲状腺功能障碍是生活中常见的甲状腺疾病，其症状不具有特异性，因此对患者进行甲状腺功能障碍的诊断非常重要。白蛋白（ALB）可以作为一种将甲状腺激素携带到其作用部位的方式，从而实现甲状腺激素向组织的快速传递。本研究旨在探讨成年人血清 ALB 水平与总三碘甲状腺原氨酸（TT3）之间的关系。
使用多变量逻辑回归模型，利用 2007-2012 年全国健康和营养检查调查（NHANES）的数据来检查 ALB 与 TT3 之间的关系。还使用了拟合平滑曲线和广义加权模型。
分析共纳入 7933 名参与者，我们发现参与者中 ALB 与 TT3 之间存在独立的正相关关系[0.006（0.003，0.009）]。在男性中，ALB 与 TT3 之间存在显著的正相关关系，而在女性中，ALB 与 TT3 之间存在显著的负相关关系。此外，我们的研究表明，ALB 和 TT3 水平之间的独立关联在非西班牙裔白种人中是显著的，但在非西班牙裔黑种人中则不显著。值得注意的是，我们在总参与者（ALB 拐点：41g/L）和调整后的协变量女性中发现了 ALB 与血清 TT3 之间的 U 形关联（ALB 拐点：46g/L）。
我们发现血清 ALB 与 TT3 之间呈 U 形关系，ALB 的拐点为 41g/L，这可能为未来筛查甲状腺功能障碍的成年人提供参考。
