Center for Retrovirus Research, The Ohio State University, Columbus, OH 43210, USA; Department of Veterinary Biosciences, The Ohio State University, Columbus, OH 43210, USA; Molecular, Cellular, and Developmental Biology Program, The Ohio State University, Columbus, OH 43210, USA.
Center for Retrovirus Research, The Ohio State University, Columbus, OH 43210, USA; Department of Veterinary Biosciences, The Ohio State University, Columbus, OH 43210, USA.
Cell Host Microbe. 2022 Aug 10;30(8):1093-1102.e3. doi: 10.1016/j.chom.2022.04.014. Epub 2022 Apr 25.
Recent reports of SARS-CoV-2 Omicron variant sub-lineages, BA.1, BA.1.1, and BA.2, have reignited concern over potential escape from vaccine- and infection-induced immunity. We examine the sensitivity of these sub-lineages and other major variants to neutralizing antibodies from mRNA-vaccinated and boosted individuals, as well as recovered COVID-19 patients, including those infected with Omicron. We find that all Omicron sub-lineages, especially BA.1 and BA.1.1, exhibit substantial immune escape that is largely overcome by mRNA vaccine booster doses. While Omicron BA.1.1 escapes almost completely from neutralization by early-pandemic COVID-19 patient sera and to a lesser extent from sera of Delta-infected patients, BA.1.1 is sensitive to Omicron-infected patient sera. Critically, all Omicron sub-lineages, including BA.2, are comparably neutralized by Omicron patient sera. These results highlight the importance of booster vaccine doses for protection against all Omicron variants and provide insight into the immunity from natural infection against Omicron sub-lineages.
最近有关 SARS-CoV-2 奥密克戎变异株亚谱系 BA.1、BA.1.1 和 BA.2 的报告再次引发了人们对疫苗和感染诱导的免疫可能逃逸的担忧。我们研究了这些亚谱系以及其他主要变体对 mRNA 疫苗接种和加强免疫个体以及已康复的 COVID-19 患者（包括感染奥密克戎的患者）产生的中和抗体的敏感性。我们发现，所有奥密克戎亚谱系，特别是 BA.1 和 BA.1.1，都表现出显著的免疫逃逸，而 mRNA 疫苗加强剂量在很大程度上克服了这种逃逸。虽然奥密克戎 BA.1.1 几乎完全逃避了早期大流行期间 COVID-19 患者血清和在较小程度上逃避了感染德尔塔变异株患者血清的中和作用，但 BA.1.1 对奥密克戎感染患者血清敏感。至关重要的是，所有奥密克戎亚谱系，包括 BA.2，都被奥密克戎患者血清同等中和。这些结果强调了加强疫苗剂量对预防所有奥密克戎变体的重要性，并提供了对自然感染奥密克戎亚谱系免疫的深入了解。
