Alzubaidi Ahmad N, Sekoulopoulos Stephen, Pham Jonathan, Walter Vonn, Fuletra Jay G, Raman Jay D
Department of Urology, Penn State Health Milton S. Hershey Medical Center, Hershey, PA, USA.
Penn State College of Medicine, Penn State Health Milton S. Hershey Medical Center, Hershey, PA, USA.
J Kidney Cancer VHL. 2022 Apr 18;9(2):7-12. doi: 10.15586/jkcvhl.v9i2.219. eCollection 2022.
Nationwide databases have implicated an increased incidence of renal cell carcinoma (RCC). The Pennsylvania (PA) Cancer Registry was queried to better define incidence, geographic distribution, and statewide trends of new RCC cases over a 27-year period. JoinPoint Trend Analysis Software modeled average annual percent changes (APCs) in age-adjusted rates (AAR). Maps plotting county-level incidence rates and stage distribution of disease across the state in 5-year time intervals were created using R 4.0.2 software. Overall, 59,628 cases of RCC were recorded in PA from 1990 to 2017. Eighty six percent of patients were >50 years of age, 61% were males, and 89% were Caucasian. Stage distribution using the SEER staging system included 64% local, 17% regional, and 16% distant. Over the study interval, AAR of all RCC cases increased from 9.9 to 18.0 patients per 100,000 population with an APC of 2.3% (p < 0.01). AAR of local disease increased from 5.4 to 12.7 patients per 100,000 population with an APC of 3.2% (p < 0.01). AAR of regional disease also increased from 1.9 to 2.9 patients per 100,000 population with an APC of 1.0% (p = 0.01). Younger patients (<50 years) had a greater rate of increase than older counterparts (APC 3.8% vs. 2.0%, p < 0.05). Geospatial investigation of new RCC cases noted certain geographic concentrations of greater disease incidence. The incidence of RCC in PA has increased over the past 27 years in PA. One-third of the cases are regional or metastatic at presentation and rates of increase were most notable in younger patients.
全国性数据库显示肾细胞癌（RCC）的发病率有所上升。我们查询了宾夕法尼亚州（PA）癌症登记处的数据，以更好地确定27年间新RCC病例的发病率、地理分布和全州趋势。JoinPoint趋势分析软件对年龄调整率（AAR）的年均变化百分比（APC）进行了建模。使用R 4.0.2软件绘制了该州各县发病率和疾病分期分布的地图，时间间隔为5年。总体而言，1990年至2017年期间，宾夕法尼亚州共记录了59628例RCC病例。86%的患者年龄大于50岁，61%为男性，89%为白种人。使用SEER分期系统的分期分布包括64%为局部期、17%为区域期和16%为远处转移期。在研究期间，所有RCC病例的AAR从每10万人中9.9例增加到18.0例，APC为2.3%（p<0.01）。局部疾病的AAR从每10万人中5.4例增加到12.7例，APC为3.2%（p<0.01）。区域疾病的AAR也从每10万人中1.9例增加到2.9例，APC为1.0%（p=0.01）。年轻患者（<50岁）的增长率高于老年患者（APC分别为3.8%和2.0%，p<0.05）。对新RCC病例的地理空间调查发现了某些疾病发病率较高的地理聚集区。在过去27年里，宾夕法尼亚州RCC的发病率有所上升。三分之一的病例在就诊时为区域期或转移期，且年轻患者的发病率上升最为显著。
