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Genetic control of translational fidelity in yeast: molecular cloning and analysis of the allosuppressor gene SAL3.

作者信息

Crouzet M, Tuite M F

机构信息

Biological Laboratory, University of Kent, Canterbury, UK.

出版信息

Mol Gen Genet. 1987 Dec;210(3):581-3. doi: 10.1007/BF00327216.

DOI:10.1007/BF00327216
PMID:3323850
Abstract

The fidelity of translation in the yeast Saccharomyces cerevisiae is controlled by a number of gene products. We have begun a molecular analysis of such genes and here describe the cloning and analysis of one of these genes, SAL3. Mutations at this locus, and at least four other unlinked loci (designated SAL1-SAL5), increase the efficiency of the tRNA ochre suppressor SUQ5, and are thus termed allosuppressors. We have cloned the SAL3 gene from a yeast genomic library by complementation of a sal3 mutation. Integration of the cloned sequence into the yeast chromosome was used to confirm that the SAL3 gene had been cloned. SAL3 gene is present in a single copy in the yeast genome, is transcribed into a 2.3-kb polyadenylated mRNA and encodes a protein of Mr 80,000. The size of the SAL3 gene product strongly suggests that it is not a ribosomal protein.

摘要

相似文献

1
Genetic control of translational fidelity in yeast: molecular cloning and analysis of the allosuppressor gene SAL3.
Mol Gen Genet. 1987 Dec;210(3):581-3. doi: 10.1007/BF00327216.
2
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Curr Genet. 1988 Dec;14(6):537-43. doi: 10.1007/BF00434078.
3
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Genetics. 1987 Mar;115(3):451-60. doi: 10.1093/genetics/115.3.451.
4
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Mol Gen Genet. 1992 Oct;235(1):64-73. doi: 10.1007/BF00286182.
5
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Mol Microbiol. 1996 Jun;20(6):1135-43. doi: 10.1111/j.1365-2958.1996.tb02634.x.
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Isolation of the SUP45 omnipotent suppressor gene of Saccharomyces cerevisiae and characterization of its gene product.酿酒酵母SUP45全能抑制基因的分离及其基因产物的特性分析。
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Nucleic Acids Res. 1992 Dec 11;20(23):6339-46. doi: 10.1093/nar/20.23.6339.
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Genetics. 1994 Nov;138(3):597-608. doi: 10.1093/genetics/138.3.597.

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Sit4p protein phosphatase is required for sensitivity of Saccharomyces cerevisiae to Kluyveromyces lactis zymocin.Sit4p蛋白磷酸酶是酿酒酵母对乳酸克鲁维酵母酶菌素敏感性所必需的。
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3
The yeast non-Mendelian factor [ETA+] is a variant of [PSI+], a prion-like form of release factor eRF3.

本文引用的文献

1
Synergistic action of genetic and phenotypic suppression of nonsense mutations in yeast Saccharomyces cerevisiae.酿酒酵母中无义突变的遗传抑制和表型抑制的协同作用。
Mol Gen Genet. 1981;183(1):197-8. doi: 10.1007/BF00270162.
2
Misreading of the ribosomal suppressor SUP46 due to an altered 40 S subunit in yeast.由于酵母中40 S亚基改变导致核糖体抑制因子SUP46的误读。
J Mol Biol. 1981 Apr 15;147(3):381-90. doi: 10.1016/0022-2836(81)90490-3.
3
An antisuppressor that acts on omnipotent suppressors in yeast.一种作用于酵母中全能抑制子的抗抑制子。
酵母非孟德尔因子[ETA+]是[PSI+]的一种变体，[PSI+]是释放因子eRF3的一种朊病毒样形式。
EMBO J. 1999 Mar 1;18(5):1182-91. doi: 10.1093/emboj/18.5.1182.
4
Overexpression of human release factor 1 alone has an antisuppressor effect in human cells.单独过表达人释放因子1在人细胞中具有反抑制作用。
Mol Cell Biol. 1997 Jun;17(6):3164-72. doi: 10.1128/MCB.17.6.3164.
5
In Xenopus laevis, the product of a developmentally regulated mRNA is structurally and functionally homologous to a Saccharomyces cerevisiae protein involved in translation fidelity.在非洲爪蟾中，一种受发育调控的信使核糖核酸的产物在结构和功能上与酿酒酵母中一种参与翻译保真度的蛋白质同源。
Mol Cell Biol. 1993 May;13(5):2815-21. doi: 10.1128/mcb.13.5.2815-2821.1993.
6
The SUP35 omnipotent suppressor gene is involved in the maintenance of the non-Mendelian determinant [psi+] in the yeast Saccharomyces cerevisiae.SUP35全能抑制基因参与酿酒酵母中[psi+]非孟德尔决定因子的维持。
Genetics. 1994 Jul;137(3):671-6. doi: 10.1093/genetics/137.3.671.
7
The dominant PNM2- mutation which eliminates the psi factor of Saccharomyces cerevisiae is the result of a missense mutation in the SUP35 gene.消除酿酒酵母ψ因子的主要PNM2突变是SUP35基因错义突变的结果。
Genetics. 1994 Jul;137(3):659-70. doi: 10.1093/genetics/137.3.659.
8
Polypeptide chain termination in Saccharomyces cerevisiae.酿酒酵母中的多肽链终止
Curr Genet. 1994 May;25(5):385-95. doi: 10.1007/BF00351776.
9
Two Saccharomyces cerevisiae genes which control sensitivity to G1 arrest induced by Kluyveromyces lactis toxin.两个控制酿酒酵母对乳酸克鲁维酵母毒素诱导的G1期阻滞敏感性的基因。
Mol Cell Biol. 1994 Sep;14(9):6306-16. doi: 10.1128/mcb.14.9.6306-6316.1994.
10
The yeast translational allosuppressor, SAL6: a new member of the PP1-like phosphatase family with a long serine-rich N-terminal extension.酵母翻译别构抑制因子SAL6：PP1样磷酸酶家族的一个新成员，其N端富含丝氨酸且有长延伸序列。
Genetics. 1994 Nov;138(3):597-608. doi: 10.1093/genetics/138.3.597.
Genetics. 1980 May;95(1):49-61. doi: 10.1093/genetics/95.1.49.
4
An antisuppressor mutation of Schizosaccharomyces pombe affects the post-transcriptional modification of the "wobble" base in the anticodon of tRNAs.粟酒裂殖酵母的一种抗抑制突变影响tRNA反密码子中“摆动”碱基的转录后修饰。
J Biol Chem. 1984 Mar 10;259(5):2856-62.
5
The effects of paromomycin on the fidelity of translation in a yeast cell-free system.巴龙霉素对酵母无细胞系统中翻译保真度的影响。
Biochim Biophys Acta. 1984 Nov 22;783(2):166-70. doi: 10.1016/0167-4781(84)90009-5.
6
Nucleotide sequence of the tcml gene (ribosomal protein L3) of Saccharomyces cerevisiae.酿酒酵母tcml基因（核糖体蛋白L3）的核苷酸序列。
J Bacteriol. 1983 Jul;155(1):8-14. doi: 10.1128/jb.155.1.8-14.1983.
7
Suppressors in yeast.酵母中的抑制因子。
Curr Top Microbiol Immunol. 1974;64(0):1-47. doi: 10.1007/978-3-642-65848-8_1.
8
Antisuppressors in yeast.酵母中的抗抑制因子。
Mol Gen Genet. 1973 Aug 28;124(4):305-20. doi: 10.1007/BF00267660.
9
Mutants of the elongation factor EF-Tu, a new class of nonsense suppressors.延伸因子EF-Tu的突变体，一类新型无义抑制子。
EMBO J. 1985 Apr;4(4):1049-52. doi: 10.1002/j.1460-2075.1985.tb03737.x.
10
Altered 40 S ribosomal subunits in omnipotent suppressors of yeast.酵母全能抑制子中改变的40 S核糖体亚基。
J Mol Biol. 1986 Mar 20;188(2):207-14. doi: 10.1016/0022-2836(86)90305-0.