一种基于激发态分子内质子转移（ESIPT）机制的用于选择性测定次氯酸（HClO）的新型比率荧光探针及其在实际样品中的应用。
A novel ratiometric fluorescent probe for the selective determination of HClO based on the ESIPT mechanism and its application in real samples.
作者信息
Li Jingrui, Gong Aijun, Shi Guoqing, Chai Chengwen
机构信息
School of Chemistry and Biological Engineering, University of Science and Technology Beijing Beijing 100083 China
Beijing Key Laboratory for Science and Application of Functional Molecular and Crystalline Materials, University of Science and Technology Beijing Beijing 100083 China.
出版信息
RSC Adv. 2019 Sep 30;9(53):30943-30951. doi: 10.1039/c9ra04569d. eCollection 2019 Sep 26.
Based on the ESIPT fluorescence mechanism, herein, a novel ratiometric fluorescent probe was designed and synthesized for the detection of HClO. The reaction site of diaminomaleonitrile at the -position of the phenolic hydroxyl group made the probe exhibit a ratiometric fluorescence response towards hypochlorous acid (HClO). The specific sensing mechanism was verified MS, HPLC and H NMR spectroscopy. Moreover, the probe showed excellent performance with high sensitivity and good selectivity towards HClO in the presence of other reactive oxygen species. In addition, the probe was successfully applied to detect HClO spiked in tap water, river water and diluted human serum with good recoveries.
基于激发态分子内质子转移（ESIPT）荧光机制，本文设计并合成了一种用于检测次氯酸（HClO）的新型比率荧光探针。二氨基马来腈在酚羟基对位的反应位点使该探针对次氯酸（HClO）呈现比率荧光响应。通过质谱（MS）、高效液相色谱（HPLC）和核磁共振氢谱（¹H NMR）对具体传感机制进行了验证。此外，该探针在存在其他活性氧物种的情况下，对HClO表现出高灵敏度和良好选择性的优异性能。另外，该探针已成功应用于检测添加到自来水、河水和稀释人血清中的HClO，回收率良好。
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