Tai Shih-Huang, Kuo Ping-Chung, Hung Ching-Che, Lin Ying-Hsuan, Hwang Tsong-Long, Lam Sio Hong, Kuo Daih-Huang, Wu Jin-Bin, Hung Hsin-Yi, Wu Tian-Shung
Departments of Surgery and Anesthesiology, Institute of Biomedical Engineering, National Cheng Kung University, Medical Center and Medical School Tainan 701 Taiwan.
School of Pharmacy, College of Medicine, National Cheng Kung University Tainan 70101 Taiwan
RSC Adv. 2019 Oct 23;9(59):34184-34195. doi: 10.1039/c9ra05899k.
Twelve undescribed sesquiterpenoids, fomitopins A-L (1-12), were isolated bioassay-guided purification from the bracket fungus (Sw.) P. Karst, and this fungus have been reported to exhibit anti-microbial and anti-inflammatory activities. The structures of 1-12 were elucidated by spectroscopic and spectrometric analyses and their absolute configurations were further confirmed by ECD simulations. Ten isolated compounds were evaluated for their anti-inflammatory potential and compound 11 exhibited the most significant inhibition of superoxide anion generation and elastase release with IC values of 0.81 ± 0.15 and 0.74 ± 0.12 μM. These newly purified sesquiterpenoids could be potential candidates for further anti-inflammatory studies.
通过生物活性导向的纯化方法，从多孔菌（Sw.）P. Karst中分离出12种未描述的倍半萜类化合物，即fomitopins A-L（1-12），据报道这种真菌具有抗菌和抗炎活性。通过光谱和波谱分析阐明了1-12的结构，并通过ECD模拟进一步确定了它们的绝对构型。对10种分离出的化合物进行了抗炎潜力评估，化合物11对超氧阴离子生成和弹性蛋白酶释放的抑制作用最为显著，IC值分别为0.81±0.15和0.74±0.12μM。这些新纯化的倍半萜类化合物可能是进一步抗炎研究的潜在候选物。
